Effect of HER2 and Fascin expression on muscle-invasive bladder cancers: Classification by basaloid and luminal phenotypes

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dc.authorscopusid57720962100
dc.authorscopusid56904163300
dc.authorscopusid57720994600
dc.contributor.authorArslan, A.I.
dc.contributor.authorKarabağ, S.
dc.contributor.authorAkgül, Murat
dc.date.accessioned2023-04-20T08:04:16Z
dc.date.available2023-04-20T08:04:16Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: The present study aims to identify basaloid and luminal molecular groups and the p53-like sub-group, which is a sub-group of the luminal group, using a specific immunohistochemical panel and investigate human epithelial growth factor receptor 2 (HER2)/Neu and Fascin expression in these groups to analyze their relationship with clinicopathological features and prognosis in a cohort of cases with muscle-invasive urothelial bladder carcinoma (MIBC). Material and Methods: An immunohistochemical panel that included GATA-3, CK20, CD44, and CK5/6 was used to identify molecular sub-groups based on expression in 44 cases of MIBC. HER2/Neu and Fascin expression in basal, luminal, and p53-like groups and the relationship with clinicopathological features and prognosis were investigated. Results: The distribution of the molecular sub-groups determined by immunohistochemistry was as follows: 23 luminal cases (52.3%), 16 basal cases (36.4%), and 5 (11.4%) p53-like cases. There was a statistically significant difference in tumor size across the groups, with the greatest size in the p53-like group (p = 0.001). A statistically significant difference was observed in HER2/Neu expression between the molecular sub-groups (p = 0.017). Comparison of survival and HER2/Neu scores revealed shorter survival in patients with an HER2/Neu score of 3 + compared to those with scores of 0, 1+, and 2+ (p = 0.109). Fascin immunoreactivity was more common in the p53-like and basal groups compared to the luminal group (p = 0.036). Conclusion: Despite the limited number of cases in the MIBC group, our results support that HER2/Neu expression in the luminal sub-group and Fascin expression in basal and p53-like groups may be used as a negative prognostic marker. Multi-center studies that include large case series are warranted in this field.
dc.identifier.doi10.4103/ijpm.ijpm_537_21
dc.identifier.endpage609
dc.identifier.issn0974-5130
dc.identifier.issue3en_US
dc.identifier.pmid35900488
dc.identifier.scopus2-s2.0-85135202946
dc.identifier.scopusqualityQ3
dc.identifier.startpage604
dc.identifier.urihttps://doi.org/10.4103/ijpm.ijpm_537_21
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11060
dc.identifier.volume65
dc.identifier.wosWOS:000935829800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArslan, A.I.
dc.institutionauthorKarabağ, S.
dc.institutionauthorAkgül, Murat
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofIndian journal of pathology & microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBasal
dc.subjectbladder cancer
dc.subjectfascin
dc.subjectHER2/Neu
dc.subjectimmunohistochemistry
dc.subjectluminal
dc.subjectp53-like
dc.subjectactin binding protein
dc.subjectcarrier protein
dc.subjectepidermal growth factor receptor 2
dc.subjectfascin
dc.subjectprotein p53
dc.subjecttumor marker
dc.subjectbladder tumor
dc.subjectbreast tumor
dc.subjectfemale
dc.subjectgenetics
dc.subjecthuman
dc.subjectmetabolism
dc.subjectmuscle
dc.subjectpathology
dc.subjectphenotype
dc.subjectprognosis
dc.subjectBiomarkers, Tumor
dc.subjectBreast Neoplasms
dc.subjectCarrier Proteins
dc.subjectFemale
dc.subjectHumans
dc.subjectMicrofilament Proteins
dc.subjectMuscles
dc.subjectPhenotype
dc.subjectPrognosis
dc.subjectReceptor, ErbB-2
dc.subjectTumor Suppressor Protein p53
dc.subjectUrinary Bladder Neoplasms
dc.titleEffect of HER2 and Fascin expression on muscle-invasive bladder cancers: Classification by basaloid and luminal phenotypes
dc.typeArticle

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