The Effect of Udenafil on Stasis Zone in an Experimental Burn Model

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dc.authorid0000-0001-8135-6444
dc.authorscopusid57203002887
dc.authorscopusid40260999700
dc.authorscopusid57397839600
dc.authorscopusid50861269700
dc.authorscopusid57217029494
dc.authorscopusid57398024000
dc.authorscopusid6701914821
dc.authorwosidUral, Alper/T-4637-2018
dc.contributor.authorUral, Alper
dc.contributor.authorBilgen, Fatma
dc.contributor.authorAltıntaş Aykan, Duygun
dc.contributor.authorKoçarslan, Sezen
dc.contributor.authorAltıntaş Ural, Dilan
dc.contributor.authorSeyithanoğlu, Muhammet
dc.contributor.authorBekerecioğlu, Mehmet
dc.date.accessioned2022-05-11T14:36:53Z
dc.date.available2022-05-11T14:36:53Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description42nd National E-Congress -- OCT 23, 2020 -- ELECTR NETWORK
dc.description.abstractBackground Management of the burn injuries is still a problematic issue because the stasis zone may become necrotic. We hypothesized that udenafil, a potent phospodiesterase inhibitor, can be beneficial in burn treatment by enhancing the viability of the stasis zone. Methods Fifteen Wistar rats were randomly divided into 3 groups. Comb burn injury model was conducted bilaterally on the back of rats in each subject. Group 1 received 1 mL/d of saline orally for 7 days. Group 2 received 10 mg/kg per day of udenafil for 7 days. Group 3 received 20 mg/kg per day of udenafil for 7 days. At the end of seventh day, gross morphological and histopathological samples of stasis zone survival were evaluated. Results Histopathological examination of groups 2 and 3 revealed that the stasis zone was mostly viable. The mean necrotic area and severity of inflammation was significantly higher in the control group compared with the treatment groups. Significant differences were determined in treatment groups compared with control group in terms of vital stasis zone area and histopathological parameters. Conclusions Udenafil treatment improved tissue survival on zone of stasis in. Future experimental studies should be conducted to develop zone of stasis treatment protocols combining udenafil with potent anti-inflammatory and antioxidant drugs.
dc.identifier.doi10.1097/SAP.0000000000003045
dc.identifier.endpage43
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue1en_US
dc.identifier.pmid34928244
dc.identifier.scopus2-s2.0-85122277601
dc.identifier.scopusqualityQ2
dc.identifier.startpage38
dc.identifier.urihttps://doi.org/10.1097/SAP.0000000000003045
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8459
dc.identifier.volume88
dc.identifier.wosWOS:000731698400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilgen, Fatma
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAnnals of Plastic Surgery
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectburns
dc.subjectinjury
dc.subjectudenafil
dc.subjectzone of stasis
dc.subjectPhosphodiesterase 5 Inhibitor
dc.subjectPharmacokinetics
dc.subjectSildenafil
dc.subjectApoptosis
dc.subjectRat
dc.subjectAutophagy
dc.subjectSurvival
dc.titleThe Effect of Udenafil on Stasis Zone in an Experimental Burn Model
dc.typeConference Object

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