Association of colon adenomas and skin tags: coincidence or coexistence?

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dc.authorid0000-0003-0000-5568
dc.authorscopusid55881189500
dc.authorscopusid27867662800
dc.authorscopusid36608599700
dc.authorscopusid25932306600
dc.authorscopusid55445082300
dc.authorscopusid7102765266
dc.authorscopusid56199979000
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidErfan, Gamze/W-8139-2018
dc.contributor.authorOran, Mustafa
dc.contributor.authorErfan, Gamze
dc.contributor.authorMete, Rafet
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorYıldırım, Oğuzhan
dc.contributor.authorAydın, M.
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:10:14Z
dc.date.available2022-05-11T14:10:14Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVES: Skin tag (STs) are benign connective tissue tumors of the dermis. Some researchers have argued that there is a relationship between skin tag and colon polyps, although the physiopathological mechanisms underlying this relation were not well elucidated. In this study we aimed to investigate the co-existence of colonic adenomatous polyps and ST, additionally to shed light on the physiopathological mechanisms underlying this coincidence. PATIENTS AND METHODS: A total of 45 patients aged between 18 and 60 diagnosed with adenomatous colonic polyps and 45 sex, age, and socio-demographically matched subjects, had no polyps, were enrolled as the control group. Routine blood analysis of all participants, including serum glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), (high-density lipoprotein cholesterol (HDL-C), triglyceride, insulin, IGF-1, and EGF, were performed. The chi-square and independent sample t or Mann Whitney U test were used to determine differences between groups. RESULTS: The number of participants with ST was significantly higher in the patient group (OR 7.067, p < 0.01). Serum levels of IGF-1 and EGF were statistically similar between the groups. In the subgroup analyses, no difference was found in serum levels of insulin, IGF-1, or EGF between patients with and without ST. However, higher serum levels of insulin and EGF were found in control subjects with ST (p < 0.01 and p < 0.01, respectively). For the entire study group, 67 participants had ST and 23 patients did not. Serum insulin, and IGF-1 were similar, while serum EGF levels were higher in patients with ST (p < 0.01). CONCLUSIONS: Findings of the present study may show a co-existence of colonic polyps and ST. Although previous studies have indicated that insulin resistance may play a role in the pathogenesis of both lesions in diabetic and obese patients, we found no indication of a relationship in nondiabetic and nonobese patients with increased levels of EGF in patients with ST, suggesting an alternative pathogenesis in this patient group.
dc.identifier.endpage1077
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid24763889
dc.identifier.scopus2-s2.0-84902160863
dc.identifier.scopusqualityQ2
dc.identifier.startpage1073
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5333
dc.identifier.volume18
dc.identifier.wosWOS:000341969400019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOran, Mustafa
dc.institutionauthorErfan, Gamze
dc.institutionauthorMete, Rafet
dc.institutionauthorYanık, Mehmet Emin
dc.institutionauthorYıldırım, Oğuzhan
dc.institutionauthorAydın, M.
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdenomatous polyps
dc.subjectSkin tag
dc.subjectAcrochordon
dc.subjectIGF-1
dc.subjectInsulin
dc.subjectEGF
dc.subjectGrowth-Factor Receptors
dc.subjectColorectal Adenomas
dc.subjectInsulin-Resistance
dc.subjectMetabolic Syndrome
dc.subjectFactor-I
dc.subjectPolyps
dc.subjectRisk
dc.subjectHyperinsulinemia
dc.subjectLesions
dc.subjectMarker
dc.titleAssociation of colon adenomas and skin tags: coincidence or coexistence?
dc.typeArticle

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