Intravitreal tigecycline treatment in experimental Acinetobacter baumannii endophthalmitis

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dc.authorscopusid9733109900
dc.authorscopusid55905856300
dc.authorscopusid50263136900
dc.authorscopusid33568235700
dc.authorscopusid14520201800
dc.authorscopusid34869701000
dc.authorscopusid55913025800
dc.authorwosidHorozoglu, Fatih/AAM-4273-2021
dc.authorwosidYanyali, Ates/AAW-7594-2020
dc.authorwosidKeskinbora, Kadircan/AAM-6453-2020
dc.contributor.authorHorozo?lu, Fatih
dc.contributor.authorMetan, Gokhan
dc.contributor.authorSever, Özkan
dc.contributor.authorPercin, Duygu
dc.contributor.authorTopal, Cumhur S.
dc.contributor.authorGönen, Tansu
dc.contributor.authorYanyalı, Ateş
dc.date.accessioned2022-05-11T14:13:59Z
dc.date.available2022-05-11T14:13:59Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractPurpose: To investigate the clinical and microbiological effectivity of intravitreal tigecycline in an experimental rabbit endophthalmitis model caused by imipenem resistant Acinetobacter baumannii. Materials and Methods: Forty-eight eyes of 24 New Zealand white albino rabbits were divided into six groups (n=8 in each). The right eyes were divided into three groups and defined as infected group; left eyes were divided into three groups and defined as uninfected group. Infected group received 0.1 ml intravitreal A. baumannii suspension. Twenty-four hours after bacterial inoculation, group 1 received 1 mg/0.1 ml tigecycline and group 2 received 0.5 mg/0.1 ml tigecycline. Group 3 eyes received no treatment. In group 4, 0.1 ml of saline solution was injected. Groups 5 and 6 were received intravitreal tigecycline injection of 1 mg/0.1 ml and 0.5 mg/0.1 ml respectively. The eyes were enucleated for histopathological evaluation on the sixth day. Clinical and histological scoring systems were used to evaluate clinical and histological severity of the intraocular infection. Results: The mean clinical scores of the six groups at the sixth day were 11 +/- 1.92, 12.4 +/- 6.2, 8.5 +/- 2.7, 0, 3 +/- 1.3, and 3 +/- 1.4 respectively. Mean histopathological scores were 7.8 +/- 2.8, 7.0 +/- 1.5, 5.6 +/- 1.4, 0, 0, and 0 respectively. There was no significant difference in mean clinical and histopathological scores of infected group ( groups 1, 2 and 3). There was significant difference in mean clinical scores of groups 5 and 6 compared with group 4. Groups 4, 5 and 6 showed normal histological structure in histopathological evaluation and showed no significant difference. Microbiological cure was achieved in all infected eyes. Conclusions: Experimental rabbit endophthalmitis model caused by imipenem resistant A. baumannii was microbiologically cured by intravitreal tigecycline injection. However, a hypersensitivity-like reaction due to intravitreal application of tigecycline limits the use of this antimicrobial agent in A. baumannii endophthalmitis.
dc.description.sponsorshipNamik Kemal University (NKUBAP)Namik Kemal University
dc.description.sponsorshipThe authors are grateful to Lenie Dijkshoorn (Department of Microbiology, Leiden University Medical Centre) for Amplified fragment length polymorphism analysis of A. baumannii. This study was supported by Scientific Research Projects Fund of Namik Kemal University (NKUBAP).
dc.identifier.doi10.1179/1120009X12Z.00000000018
dc.identifier.endpage106
dc.identifier.issn1120-009X
dc.identifier.issue2en_US
dc.identifier.pmid22546766
dc.identifier.scopus2-s2.0-84866248143
dc.identifier.scopusqualityQ3
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1179/1120009X12Z.00000000018
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5727
dc.identifier.volume24
dc.identifier.wosWOS:000303126800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHorozo?lu, Fatih
dc.institutionauthorSever, Özkan
dc.institutionauthorGönen, Tansu
dc.language.isoen
dc.publisherManey Publishing
dc.relation.ispartofJournal of Chemotherapy
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcinetobacter baumannii
dc.subjectTigecycline
dc.subjectIntravitreal antibiotic
dc.subjectExperimental endophthalmitis
dc.subjectImipenem resistant Acinetobacter
dc.subjectStaphylococcus-Epidermidis
dc.subjectMicrobiological Outcomes
dc.subjectInfections
dc.subjectPharmacokinetics
dc.subjectVitrectomy
dc.subjectResistance
dc.titleIntravitreal tigecycline treatment in experimental Acinetobacter baumannii endophthalmitis
dc.typeReview Article

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