METASTATİK KÜÇÜK HÜCRELİ DIŞI AKCİĞER KANSERLİ HASTALARIN DEMOGRAFİK ÖZELLİKLERİNİN DEĞERLENDİRİLMESİ
Yükleniyor...
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Namık Kemal Üniversitesi, Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Akciğer kanseri dünyada en sık görülen kanserdir ve her iki cinsiyette de kansere bağlı ölümlerin başta gelen nedenleri arasındadır. Tanı ve tedavi sürecindeki gelişmelere rağmen, bu hastalardaki genel sağkalım sürelerinin halihazırda kısa olduğu görülmektedir. Bu çalışmada küçük hücreli dışı metastatik akciğer kanserli hastaların demografik özelikleri incelenmiş ve bu faktörlerin sağkalım üzerine olan etkisi değerlendirilmiştir. Materyal ve Metot: Çalışmamıza Namık Kemal Üniversitesi Tıp Fakültesi Hastanesi Medikal Onkoloji Kliniğinde 2010-2016 yılları arasında metastatik küçük hücreli dışı akciğer kanseri tanısı alarak çalışmaya kabul kriterlerini karşılayan 102 hasta dahil edildi. Hastaların tedavi öncesi demografik özellikleri incelendi ve bu özelliklerin prognoz ile ilişkisini gösterebilecek istatistiksel incelemeler yapıldı. Bulgular: Çalışmaya kabul kriterlerini karşılayan 102 hasta çalışmaya dahil edildi. Hastaların tedavi öncesi kayıt altına alınmış olan demografik özellikleri incelendi. Çalışma grubundaki hastaların median genel sağkalım süresi 10 ay ve median progresyonsuz sağkalım süresi 6 ay olarak bulundu. Klinik parametrelere bakıldığında, ECOG Performans Skorunun 0-1 olması, yaşın ?70 olması, tek bir bölgede metastaza sahip olunmasının daha uzun median genel sağkalım ile ilişkili olduğu saptandı. Multivariate cox regresyon analizinde ise sadece metastaz sayısı sağkalım için bağımsız prediktif değer olarak bulundu. Sonuç: Bu çalışma , metastaz sayısının metastatik küçük hücreli dışı akciğer kanserli hastalarda kötü prognozun tahmin edilmesine yardımcı olabileceğini göstermiştir.
Aim: Lung cancer is the most common cancer in the world and is one of the leading causes of cancer-related deaths in both sexes. Despite improvements in treatment and duration of treatment, overall survival in these patients is still short. In this study, the demographic characteristics of patients with non-small cell metastatic lung cancer were examined and the effect of these factors on survival was evaluated. Materials and Methods: The study included 102 patients with metastatic non-small cell lung cancer who met the criteria for admission to study between 2010-2016 at Namık Kemal University Hospital Medical Oncology Clinic. Pre-treatment demographic characteristics of the patients were examined and a statistical analysis was performed to show the relationship between these characteristics and prognosis. Results: 102 patients who met the Study Admission criteria were included in the study. Demographic characteristics of patients were recorded before treatment. Patients in the study group had a median overall survival time of 10 months and a median progression-free survival time of 6 months. When clinical parameters were examined, it was determined that patients had an ECOG Performance Score of 0-1, age ?70, and that single metastasis was associated with longer overall survival. In multivariate cox regression analysis, only the number of metastases was found as an independent predictive value for survival. Conclusion: This study has shown that the number of metastases can help predict poor prognosis in patients with metastatic nonsmall cell lung cancer.
Aim: Lung cancer is the most common cancer in the world and is one of the leading causes of cancer-related deaths in both sexes. Despite improvements in treatment and duration of treatment, overall survival in these patients is still short. In this study, the demographic characteristics of patients with non-small cell metastatic lung cancer were examined and the effect of these factors on survival was evaluated. Materials and Methods: The study included 102 patients with metastatic non-small cell lung cancer who met the criteria for admission to study between 2010-2016 at Namık Kemal University Hospital Medical Oncology Clinic. Pre-treatment demographic characteristics of the patients were examined and a statistical analysis was performed to show the relationship between these characteristics and prognosis. Results: 102 patients who met the Study Admission criteria were included in the study. Demographic characteristics of patients were recorded before treatment. Patients in the study group had a median overall survival time of 10 months and a median progression-free survival time of 6 months. When clinical parameters were examined, it was determined that patients had an ECOG Performance Score of 0-1, age ?70, and that single metastasis was associated with longer overall survival. In multivariate cox regression analysis, only the number of metastases was found as an independent predictive value for survival. Conclusion: This study has shown that the number of metastases can help predict poor prognosis in patients with metastatic nonsmall cell lung cancer.
Açıklama
Anahtar Kelimeler
Küçük hücreli dışı akciğer kanseri, demografik özellikler, prognoz, Non small cell lung cancer, demographic characteristics, prognosis
Kaynak
Namık Kemal Tıp Dergisi (International Journal of Basic and Clinical Medicine)
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
1
