The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy

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dc.authorscopusid56715752200
dc.authorscopusid8514414100
dc.authorscopusid57200105523
dc.authorscopusid55767454000
dc.authorscopusid57190404723
dc.authorscopusid57004462100
dc.authorscopusid56117583100
dc.contributor.authorBilir, Bülent
dc.contributor.authorTülübaş, Feti
dc.contributor.authorBilir, Betül Ekiz
dc.contributor.authorAtile, N.S.
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorYıldırım, Tülay
dc.contributor.authorAydın, M.
dc.date.accessioned2022-05-11T14:10:03Z
dc.date.available2022-05-11T14:10:03Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstract[Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls. [Subjects and Methods] A single-blind controlled clinical study was performed, including70 type 2 diabetic patients with or without diabetic peripheral neuropathy and 33 healthy volunteer controls. The 25(OH)D levels were evaluated using ultra-performance liquid chromatography, and IL-17 and IL-13 levels were assessed using enzyme-linked immunosorbent assays. [Results] The 25(OH) vitamin D concentration was lower in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy and healthy controls. Similarly, 25(OH)D levels were lower in diabetes mellitus patients than healthy controls. IL-17 and IL-13 levels were higher in diabetes mellitus patients than in controls. Additionally, IL-13 levels were higher in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy. These differences were statistically significant. There was a significant positive correlation between 25(OH)D and IL-13,and a negative correlation between 25(OH) D andIL-17 in the diabetic and diabetic neuropathy groups. [Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13. © 2016 The Society of Physical Therapy Science.
dc.identifier.doi10.1589/jpts.28.2159
dc.identifier.endpage2163
dc.identifier.issn0915-5287
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-84979744522
dc.identifier.scopusqualityN/A
dc.identifier.startpage2159
dc.identifier.urihttps://doi.org/10.1589/jpts.28.2159
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5265
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.institutionauthorBilir, Bülent
dc.institutionauthorTülübaş, Feti
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorYıldırım, Tülay
dc.language.isoen
dc.publisherSociety of Physical Therapy Science (Rigaku Ryoho Kagakugakkai)
dc.relation.ispartofJournal of Physical Therapy Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokines
dc.subjectDiabetic peripheral neuropathy
dc.subjectVitamin D
dc.titleThe association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy
dc.typeArticle

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