Potential drug-drug interactions in university hospital medical intensive care unit patients in turkey

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dc.authorscopusid57188876195
dc.authorscopusid57367200900
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorKara, Sonat Pınar
dc.date.accessioned2022-05-11T14:12:46Z
dc.date.available2022-05-11T14:12:46Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Concomitant use of drugs not only enhances the therapeutic effect, but may also lead to undesirable interactions. Drug interactions are frequently seen in intensive care patients. In this study, we aimed to determine the frequency and clinical severity of drug interactions in Medical Intensive Care Unit (MICU) patients. PATIENTS AND METHODS: The ordered drugs and blood analysis results of 314 patients aged ?18 years who stayed in the MICU for at least 24 h between January and December 2020 were evaluated. Using the Lexi-Interact online database, clinically significant types of drug interactions, frequently interacting drug/ drug groups, and potential adverse reactions were identified. RESULTS: The average number of drugs in 314 patients was 8.98±5.19. It was determined that polypharmacy was associated with comorbidity and the amount of drug used increased as the number of diagnoses increased. Potential drugdrug interactions were observed in 69.7% of the MICU patients, and it was determined that the amount of interactions increased as the amount of drug used increased. The most common X, D, and C type potential drug-drug interactions, were found between furosemide and salbutamol, enoxaparin and acetylsalicylic acid, ipratropium and potassium chloride, respectively. CONCLUSIONS: Use of frequently interacting drugs in the treatment of critically MICU patients may lead to potential drug-drug interactions and adverse reactions. Daily monitoring and updating of drug therapy can improve patient's quality of life by preventing or reducing potential drugdrug interactions. © 2021 Verduci Editore s.r.l. All rights reserved.
dc.description.sponsorshipThis article was funded by researchers.
dc.identifier.doi10.26355/eurrev_202111_27264
dc.identifier.endpage7114
dc.identifier.issn1128-3602
dc.identifier.issue22en_US
dc.identifier.pmid34859876
dc.identifier.scopus2-s2.0-85120867784
dc.identifier.scopusqualityQ2
dc.identifier.startpage7108
dc.identifier.urihttps://doi.org/10.26355/eurrev_202111_27264
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5667
dc.identifier.volume25
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.institutionauthorKara, Sonat Pınar
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdverse reaction
dc.subjectClinical pharmacology
dc.subjectClinically significant drug-drug interactions
dc.subjectPatient safety
dc.subjectPharmacovigilance
dc.titlePotential drug-drug interactions in university hospital medical intensive care unit patients in turkey
dc.typeArticle

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