APJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease

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dc.authorid0000-0003-4720-1945
dc.authorid0000-0002-1503-329X
dc.authorscopusid35764299300
dc.authorscopusid23391660500
dc.authorscopusid56895970700
dc.authorscopusid57000520600
dc.authorscopusid56503950500
dc.authorscopusid47561138500
dc.authorscopusid57000551800
dc.authorwosidAKCILAR, Raziye/A-5351-2018
dc.authorwosidYumun, Gunduz/M-1768-2015
dc.contributor.authorAkçılar, Raziye
dc.contributor.authorYümün, Gündüz
dc.contributor.authorBayat, Zeynep
dc.contributor.authorDonbaloğlu, Mehmet Okan
dc.contributor.authorErselcan, Kubilay
dc.contributor.authorEce, Ezgi
dc.contributor.authorGenç, Osman
dc.date.accessioned2022-05-11T14:12:47Z
dc.date.available2022-05-11T14:12:47Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractCoronary artery disease (CAD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. Apelin is a novel endogenous peptide with inotropic and vasodilatory properties and is the ligand for the angiotensin receptor-like 1 (APJ) receptor. We aimed to determine genotype and allele frequencies of APJ receptor A445C gene polymorphism in Turkish patients with CAD and healthy controls by RFLP-PCR. This study was performed on 159 unrelated CAD patients and 62 healthy controls. We obtained AA, AC and CC genotype frequencies in CAD patients as 41.5%, 49.1% and 9.4%, respectively. In the control group, frequencies of genotypes were found as 35.5% for AA, 48.4% for AC and 16.1% for CC. We did not observe difference in APJ receptor A445C polymorphism between CAD patients and healthy controls (chi(2) = 2.178; df = 2; P = 0.336). The A allele was encountered in 66% (210) of the CAD and 59.7% (74) of the controls. The C allele was seen in 34% (108) of the CAD and 40.3% (50) of the controls. Allele frequencies of interested genes were not significantly different between groups (chi(2) = 1.57; df = 1; p = 0.225). The frequencies of APJ receptor A445C genotype were not significantly different between control and patients. None of the three APJ receptor A445C genotypes, AA, AC and CC displayed significant difference in CAD patients. We did not find any difference in the clinical parameters except for weight and diastolic blood pressure levels in the AA, AC and CC genotypes of patients. Individuals with CC genotypes had significantly higher weight, systolic and diastolic blood pressure levels and systolic blood pressure than other genotypes, P <= 0.05. In addition, HDL-C level was found decreased, but this reduction was not statistically significant. Contrarily, the low levels of weight, SBP, DBP and TC were statistically significant in the subjects with AA genotype in CAD. In conclusion, CC genotype carriers may have more risk than other genotypes in the development of hypertension in CAD, but not AAgenotype carriers. We suggest that this polymorphism may not be a marker of CAD, but it may cause useful in function of the apelin/APJ system and may be a genetic predisposing factor for diagnostic processes and can be helpfull in finding new treatment strategies. We think that it is required to further comprehensive studies in order to make clear this situation in CAD.
dc.identifier.endpage18799
dc.identifier.issn1940-5901
dc.identifier.issue10en_US
dc.identifier.pmid26770497
dc.identifier.scopus2-s2.0-84949649900
dc.identifier.scopusqualityN/A
dc.identifier.startpage18793
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5671
dc.identifier.volume8
dc.identifier.wosWOS:000367669800205
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYümün, Gündüz
dc.institutionauthorDonbaloğlu, Mehmet Okan
dc.institutionauthorErselcan, Kubilay
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAPJ receptor A445C gene
dc.subjectcoronary artery disease
dc.subjectpolymorphism
dc.subjectApelin
dc.subjectAssociation
dc.subjectRoles
dc.titleAPJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease
dc.typeArticle

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