Romatoid artritli hastalarda kalprotektin düzeyinin değerlendirilmesi ve egzersiz tedavisinin etkisi
Yükleniyor...
Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Namık Kemal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Romatoid artrit (RA) kronik, inflamatuvar, otoimmün bir hastalıktır. Çalışmamızda amacımız RA’da hastalık aktivitesi ve inflamatuar belirteçler ile kalprotektin düzeylerinin ilişkisini araştırmaktır. Çalışmaya 28 RA hastası ve 30 sağlıklı konrol alındı. RA’lı hastalarda kalprotektin, NO, CRP, ESH, BKS ve RF düzeyleri konrol grubuna göre anlamlı olarak yüksek saptandı (p<0.01, p<0.001, p<0.01, p<0.01, p<0.01, p<0.05 sırasıyla). Hastalık aktivitesi artmış RA’lı hastalarda (DAS-28>5.1); kalprotektin, CRP, ESH, RF, BKS ve lenfosit sayısı remisyondaki hastalara göre (DAS28<2.7) anlamlı olarak yüksek saptandı (p<0.05, p<0.001, p<0.05, p<0.01, p<0.01, p<0.05 sırasıyla). RA’lı hasta grubuna uygulanan korelasyon analizinde kalprotektin ile DAS-28, CRP, NO, RF ve BKS arasında pozitif ilişki saptandı (p<0.001, p<005, p<0.001, p<0.05, p<0.05 sırasıyla). RA’lı hastalara uygulanan 8 haftalık düşük yoğunluklu egzersiz tedavisi sonucu kalprotektin, DAS-28, NO, CRP, ESH ve RF düzeylerinde anlamlı azalma saptandı (p<0.05, p<0.001, p<0,01, p<0.05, p<0.05, p<0.05 sırasıyla). Sonuç olarak RA’da hastalık aktivitesi ile kalprotektin düzeyleri ile ve diğer inflamatuar parametreler arasında anlamlı bir ilişki bulunmuştur. Aynı zamanda kalprotektinin egzersiz tedavisinin takibinde iyi bir belirteç olarak kullanılabileceğini göstermektedir.
Rheumatoid arthritis (RA) is a chronic, inflammatory and autoimmune disease. In our study we aim to research the relation of disease activity in RA and inflammatory determiners, and the levels of calprotectin. 28 patients with RA and 30 healthy controls were included in this study. Calprotektin, NO, CRP, ESR, WBC and RF levels were significantly higher in the patient group compared to the control group (p<0.01, p<0.001, p<0.01, p<0.01, p<0.01, p<0.05, respectively). In patients with RA whose disease activity has increased (DAS-28>5.1), calprotectin, CRP, ESR, RF, WBC and lymphocyte counts are found significantly higher (p<0.05, p<0.001, p<0.05, p<0.01, p<0.01, p<0.05 respectively) than the patients in remission (DAS28<2.7). In correlation analysis applied to patient group with RA, there has been determined a positive relation with calprotectin, and DAS-28, CRP, NO, RF and WBC (p<0.001, p<005, p<0.001, p<0.05, p<0.05 respectively). In result of the low density exercise treatment applied to patients with RA for 8 weeks, there has been determined a significant decrease in DAS-28, NO, CRP, ESR and RF levels (p<0.05, p<0.001, p<0,01, p<0.05, p<0.05, p<0.05 respectively). As a result, a significant relation is found between RA disease activity and calprotectin levels and other inflammatory parameters. At the same time, it shows that calprotectin can be used as a good identifier in following up exercise treatment.
Rheumatoid arthritis (RA) is a chronic, inflammatory and autoimmune disease. In our study we aim to research the relation of disease activity in RA and inflammatory determiners, and the levels of calprotectin. 28 patients with RA and 30 healthy controls were included in this study. Calprotektin, NO, CRP, ESR, WBC and RF levels were significantly higher in the patient group compared to the control group (p<0.01, p<0.001, p<0.01, p<0.01, p<0.01, p<0.05, respectively). In patients with RA whose disease activity has increased (DAS-28>5.1), calprotectin, CRP, ESR, RF, WBC and lymphocyte counts are found significantly higher (p<0.05, p<0.001, p<0.05, p<0.01, p<0.01, p<0.05 respectively) than the patients in remission (DAS28<2.7). In correlation analysis applied to patient group with RA, there has been determined a positive relation with calprotectin, and DAS-28, CRP, NO, RF and WBC (p<0.001, p<005, p<0.001, p<0.05, p<0.05 respectively). In result of the low density exercise treatment applied to patients with RA for 8 weeks, there has been determined a significant decrease in DAS-28, NO, CRP, ESR and RF levels (p<0.05, p<0.001, p<0,01, p<0.05, p<0.05, p<0.05 respectively). As a result, a significant relation is found between RA disease activity and calprotectin levels and other inflammatory parameters. At the same time, it shows that calprotectin can be used as a good identifier in following up exercise treatment.
Açıklama
Anahtar Kelimeler
Artrit-romatoid, C reaktif protein, Egzersiz tedavisi, Eritrositler, Kalprotektin, Nitrik oksit, Arthritis-rheumatoid, C reactive protein, Exercise therapy, Erythrocytes, Calprotectin, Nitric oxide
