Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome

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dc.authorid0000-0002-3535-5704
dc.authorscopusid16315021800
dc.authorscopusid55881189500
dc.authorscopusid6505680586
dc.authorscopusid8531050000
dc.authorscopusid26532378600
dc.authorscopusid23968920100
dc.authorscopusid14047809600
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorOran, Mustafa
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAlp, Recep
dc.date.accessioned2022-05-11T14:07:35Z
dc.date.available2022-05-11T14:07:35Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIncreased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 +/- 6.5 vs 68.2 +/- 5.8 ng/mL, P = .029), higher mean cIMT (0.73 +/- 0.2 vs 0.63 +/- 0.3 mm, P < .001), and greater stiffness (beta) index (7.45 +/- 0.9 vs 5.2 +/- 0.7, P = .001) in the OSAS group. The cIMT and stiffness (beta) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.
dc.identifier.doi10.1177/0003319713497421
dc.identifier.endpage613
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue7en_US
dc.identifier.pmid23892440
dc.identifier.scopus2-s2.0-84903852686
dc.identifier.scopusqualityQ2
dc.identifier.startpage607
dc.identifier.urihttps://doi.org/10.1177/0003319713497421
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5150
dc.identifier.volume65
dc.identifier.wosWOS:000340112100011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorOran, Mustafa
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAlp, Recep
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofAngiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcarotid atherosclerosis
dc.subjectfetuin-A
dc.subjectobstructive sleep apnea
dc.subjectintima-media thickness
dc.subjectAnkle Brachial Index
dc.subjectAortic Stiffness
dc.subjectDisease
dc.subjectRisk
dc.subjectAbnormalities
dc.subjectObesity
dc.subjectStroke
dc.titleAssociation Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome
dc.typeArticle

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