Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients

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dc.authorscopusid34869282100
dc.authorscopusid8570900600
dc.authorscopusid57190404723
dc.authorscopusid55858591400
dc.authorscopusid23968920100
dc.contributor.authorBayrakçı, Nergiz
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorYılmaz, A.
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:02:52Z
dc.date.available2022-05-11T14:02:52Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground. Hypertension is one of the leading causes of cardiovascular mortality. Although the pathogenetic process involved is not yet fully understood, the disease involves endothelial damage and inflammation. Calprotectin is an inflammatory marker that rises in parallel with disease activity in conditions such as systemic inflammatory diseases, infection, and atherosclerosis. The purpose of this study was to evaluate inflammation through serum calprotectin levels in newly diagnosed primary hypertension patients. Methods. Forty-nine newly diagnosed hypertensive patients and 38 healthy adults were included in the study. Patients' office blood pressure values, biochemical findings, and demographic characteristics were recorded. Serum calprotectin levels were measured using ELISA. Parameters affecting serum calprotectin levels and determinants of hypertension were evaluated. Results. Serum calprotectin levels were 242.8 (72.4-524) ng/mL in the control group and 112.6 (67.4-389.8) ng/mL in the hypertensive patient group, the difference being statistically significant (p=0.001). There was no correlation between serum calprotectin levels and other parameters (blood pressure values, age, gender, serum creatinine, uric acid, and calcium levels) in the hypertensive group. A lower serum calprotectin level was found to be independently related to hypertension (? = -0.009, p=0.005). Serum calprotectin at a cutoff level of 128.6 ng/mL differentiated hypertensives from healthy controls with a sensitivity of 69.4% and specificity of 68.4% (AUC = 0.767). Conclusions. The results of this study were the opposite of our hypothesis that a higher calprotectin level may reflect subclinical endothelial damage in newly diagnosed hypertensive patients. Further comparative studies involving patients at different stages of hypertension may contribute to clarifying the relationship between calprotectin and hypertension. We conclude that molecular studies seem essential for understanding the place of calprotectin in hypertension-associated inflammation, a complex process. © 2022 Nergiz Bayrakci et al.
dc.identifier.doi10.1155/2022/6912502
dc.identifier.issn2090-0384
dc.identifier.scopus2-s2.0-85124151821
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1155/2022/6912502
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4519
dc.identifier.volume2022
dc.identifier.wosWOS:000767520200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBayrakçı, Nergiz
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorYılmaz, A.
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherHindawi Limited
dc.relation.ispartofInternational Journal of Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSerum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients
dc.typeArticle

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