Differences in platelet-leukocyte aggregates among subtypes of acute cerebral ischemia

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dc.authorscopusid6701664192
dc.authorscopusid6603040523
dc.authorscopusid36763790500
dc.authorscopusid15756259700
dc.authorscopusid35546856700
dc.authorscopusid7004457653
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTurgut, Nilda
dc.contributor.authorÇelik, Yahya
dc.contributor.authorTekgündüz, Emre
dc.contributor.authorPamuk, Gülsüm Emel
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2022-05-11T14:39:51Z
dc.date.available2022-05-11T14:39:51Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Acute cerebral ischemia is caused by different pathophysiological mechanisms. The role of platelets and other blood cells can be different among the stroke subtypes. Methods: Seventy-two patients with acute ischemic cerebrovascular disease, including 31 patients with large vessel disease, 21 patients with cardioembolic disease, and 20 patients with small vessel disease, were evaluated. P-selectin (CD62P) expression and platelet leukocyte aggregates were measured with flow cytometry at the acute phase after the ischemic event. Markers were also measured in 37 control subjects. In all subjects, the serum high-sensitivity C-reactive protein (CRP) was also measured. Results: The platelet-monocyte aggregates (PMA) and platelet-granulocyte aggregates (PGA) in the large vessel disease group were higher than in control group (P=0.002, and P < 0.0001, respectively). The PMA and PGA in the small vessel disease group were also higher than in the control group (P=0.004 and P < 0.0001, respectively). In contrast, in the cardioembolic disease group, the PMA and PGA were not significantly different from the control group. CD62P expression was higher in all of the patient groups relative to the control group (P < 0.05 for all comparisons). Serum CRP levels were also higher in all of the patient groups than in the control group (P < 0.0001 for all comparisons). Conclusions: In contrast to large vessel and small vessel disease, it seems that platelet-leukocyte association does not play a crucial role in the pathogenesis of cardioembolic stroke. (C) 2011 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTrakya UniversityTrakya University
dc.description.sponsorshipThis study was supported by grants from The Research Fund of Trakya University. We wish to thank S. Azcan for her valuable technical assistance.
dc.identifier.doi10.1016/j.jns.2011.02.026
dc.identifier.endpage130
dc.identifier.issn0022-510X
dc.identifier.issn1878-5883
dc.identifier.issue45323en_US
dc.identifier.pmid21440261
dc.identifier.scopus2-s2.0-79955704111
dc.identifier.scopusqualityQ2
dc.identifier.startpage126
dc.identifier.urihttps://doi.org/10.1016/j.jns.2011.02.026
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8760
dc.identifier.volume305
dc.identifier.wosWOS:000291330800022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Burhan
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of the Neurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPlatelet-monocyte aggregates
dc.subjectPlatelet-granulocyte aggregates
dc.subjectPlatelet-leukocyte interaction
dc.subjectP-selectin
dc.subjectCerebrovascular disease
dc.subjectStroke
dc.subjectSurface P-Selectin
dc.subjectActivation Markers
dc.subjectFlow-Cytometry
dc.subjectStroke
dc.subjectAdhesion
dc.subjectHemostasis
dc.subjectExpression
dc.titleDifferences in platelet-leukocyte aggregates among subtypes of acute cerebral ischemia
dc.typeArticle

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