Comparison of colorectal neoplastic polyps and adenocarcinoma with regard to NLR and PLR

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dc.authorid0000-0003-2006-9198
dc.authorid0000-0003-1584-2510
dc.authorscopusid17433815200
dc.authorscopusid7102765266
dc.authorscopusid57189216901
dc.authorscopusid55624501100
dc.authorscopusid55445082300
dc.authorscopusid15844109600
dc.authorscopusid25625782200
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.contributor.authorEmir, Seyfi
dc.contributor.authorAydın, M.
dc.contributor.authorCan, G.
dc.contributor.authorBali, İlhan
dc.contributor.authorYıldırım, Oğuzhan
dc.contributor.authorÖznur, Meltem
dc.contributor.authorGürel, A.
dc.date.accessioned2022-05-11T14:07:40Z
dc.date.available2022-05-11T14:07:40Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Cancer-related inflammation affects many aspects of malignancy, including proliferation and survival of malignant cells, angiogenesis, and therapeutic response. Some biomarkers representing the degree of systemic inflammation, such as the Glasgow prognostic score, NLR and PLR, have been shown to have prognostic value in many kinds of cancer patients. Aim of this study to investigate to compare neutrophil/leukocyte (NLR) and platelet/lymphocyte (PLR) ratios of the patients with colorectal neoplastic polyps and colorectal cancer (CRC) and tried to determine whether this could be used as a biomarker in follow up of the patients with neoplastic polyps. PATIENTS AND METHODS: A total of 100 colorectal polyps, 113 colorectal cancers and 124 healthy controls were included in the study. Exculusion criteria were endocrinologic or metabolic diseases, acute or chronic diseases, hypertension and atherosclerotic heart diseases, renal diseases. Blood count parameters of the patients were measured. The NLR was calculated as a simple ratio between the absolute neutrophil and the absolute lymphocyte counts. The PLR was defined as the platelet counts to lymphocyte ratio. RESULTS: A statistically significant difference was not detected between Group A and C with regard to NLR and PLR. NLR and PLR were found statistically significantly high in Group B (CRC), Group A (colorectal polyp) and Group C (healthy individuals) (p < 0.001 and p < 0.001). Our study showed that the optimum NLR cutoff point for neoplastic polyps was 2.28 (sensitivity: 68.7%, specificity: 42.3%). When the sensitivity and specificity levels of the PLR were assessed, they were 68.7% and 46.5% for neoplastic polyps, 80% and 68.9% for colorectal cancer. CONCLUSIONS: NLR and PLR may be used for follow up conversion of colonic and rectal neoplastic polyps to invasive tumor.
dc.identifier.endpage3618
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid26502851
dc.identifier.scopus2-s2.0-84966293247
dc.identifier.scopusqualityQ2
dc.identifier.startpage3613
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5170
dc.identifier.volume19
dc.identifier.wosWOS:000363789700014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmir, Seyfi
dc.institutionauthorAydın, M.
dc.institutionauthorCan, G.
dc.institutionauthorBali, İlhan
dc.institutionauthorYıldırım, Oğuzhan
dc.institutionauthorÖznur, Meltem
dc.institutionauthorGürel, A.
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomarker
dc.subjectColorectal cancer
dc.subjectNeutrophil lymphocyte ratio
dc.subjectPlatelet lymphocyte ratio
dc.subjectNeutrophil-Lymphocyte Ratio
dc.subjectColony-Stimulating Factor
dc.subjectElevated Preoperative Neutrophil
dc.subjectIn-Vivo
dc.subjectPrognostic Marker
dc.subjectIschemic-Stroke
dc.subjectCancer Patients
dc.subjectOvarian-Cancer
dc.subjectPlatelet
dc.subjectInflammation
dc.titleComparison of colorectal neoplastic polyps and adenocarcinoma with regard to NLR and PLR
dc.typeArticle

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