Effects of acute topiramate administration on post-traumatic stress disorder in rats

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dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorDoğan, Furkan Cuma
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorYananlı, Hasan Raci
dc.date.accessioned2022-05-11T14:02:43Z
dc.date.available2022-05-11T14:02:43Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractPurpose: The aim of this study was to investigate the effects of acute systemic topiramate administration on anxiety index and freezing time, plasma estrogen and progesterone levels, and salivary gland immunoglobulin A in a post-traumatic stress disorder rat model. Materials and Methods: A total of eighteen female Wistar rats used in the study were exposed to predatory odor stress. One week later, saline was administered to the control group and 15 mu M and 30 mu M topiramate to the treatment groups, after which the animals were exposed to the trauma reminder and their behavior was monitored in the elevated plus maze. At the end of the experiment, blood samples were taken, animals were sacrificed, salivary glands were removed immediately after. Results: Topiramate suppressed anxiety index and freezing time in rats with post-traumatic stress disorder at both 15 mu M and 30 mu M doses compared to the control group. A positive correlation was observed between plasma estrogen level and anxiety index in the control group, and topiramate suppressed this correlation in a dose-dependent manner. Topiramate did not change the plasma progesterone level, but suppressed the salivary gland immunoglobulin A level at the low dose. Conclusion: These findings obtained in our study indicate that topiramate may be effective in the treatment of post-traumatic stress disorder.
dc.description.sponsorshipTekirdag Namik Kemal University Scientific Research Projects Coordination Unit (NKUBAP)
dc.description.sponsorshipThis project was supported by Tekirdag Namik Kemal University Scientific Research Projects Coordination Unit (NKUBAP. 02.DPO.21.303) and researchers.
dc.identifier.doi10.17826/cumj.1035129
dc.identifier.endpage309
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage301
dc.identifier.trdizinid519929
dc.identifier.urihttps://doi.org/10.17826/cumj.1035129
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4455
dc.identifier.volume47
dc.identifier.wosWOS:000767959700037
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.institutionauthorDoğan, Furkan Cuma
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnxiety index
dc.subjectestrogen
dc.subjectfreezing time
dc.subjectprogesterone
dc.subjectsalivary immunoglobulin A
dc.subjectReceptor Antagonists
dc.subjectGaba(A) Receptors
dc.subjectImmunoglobulin-A
dc.subjectSex-Differences
dc.subjectAnxiety
dc.subjectProgesterone
dc.subjectExtinction
dc.subjectActivation
dc.subjectInfusions
dc.subjectResponses
dc.titleEffects of acute topiramate administration on post-traumatic stress disorder in rats
dc.typeArticle

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