Relationship between reticuloendothelial systems' FDG uptake level and clinicopathological features in patient with invasive ductal breast cancer

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dc.authorid0000-0002-3650-8258
dc.authorid0000-0002-3053-9133
dc.authorscopusid35949526800
dc.authorscopusid50461202500
dc.authorwosidELBOGA, UMUT/AAH-1320-2020
dc.authorwosidSahin, Ertan/AAG-8999-2020
dc.contributor.authorŞahin, Ertan
dc.contributor.authorElboğa, Umut
dc.date.accessioned2022-05-11T14:40:54Z
dc.date.available2022-05-11T14:40:54Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractThe reticuloendothelial system (RES) is a part of the immune system and plays a major role in the protection of against diseases. We thought that FDG-PET/CT may show the degree of systemic immune response induced with malignancy in the organs with the high RES activity. Our objective is to investigate FDG uptake levels of high RES activity organs (liver, spleen, bone marrow) in invasive ductal breast cancer and to evaluate the association with the clinicopathological features. In the present study, 193 patients with invasive ductal breast cancer who performed FDG-PET/CT were categorized according to the clinicopathological features including age, tumor size, axillary nodal status, histological grade, the presence of lymphavascular invasion, receptor status, Ki-67 proliferation index and biological subgroup. Also, a control group of 100 subjects were identified for comparison with breast cancer patients. We analyzed the relation of FDG uptake levels in high RES activity organs and clinicopathological features in patients. There was a statistically significant difference of SUVmax of the liver, spleen, and bone marrow between cancer and control groups (P < 0.0001). We found that high SUVmax in liver, spleen and bone marrow were significantly correlated with worse prognostic clinicopathological features in patient with invasive ductal breast cancer. FDG uptake level in high RES activity organs is associated with the presence of tumor, and also directly relating clinicopathological features for patients with invasive ductal breast cancer.
dc.identifier.doi10.1007/s11547-017-0779-x
dc.identifier.endpage792
dc.identifier.issn0033-8362
dc.identifier.issn1826-6983
dc.identifier.issue10en_US
dc.identifier.pmid28597239
dc.identifier.scopus2-s2.0-85020634421
dc.identifier.scopusqualityQ1
dc.identifier.startpage785
dc.identifier.urihttps://doi.org/10.1007/s11547-017-0779-x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8962
dc.identifier.volume122
dc.identifier.wosWOS:000410731500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Ertan
dc.language.isoen
dc.publisherSpringer-Verlag Italia Srl
dc.relation.ispartofRadiologia Medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectReticuloendothelial system
dc.subjectFDG
dc.subjectClinicopathological features
dc.subjectBreast cancer
dc.subjectPhagocytic Function
dc.subjectF-18-Fdg Uptake
dc.subjectMacrophages
dc.subjectGrowth
dc.titleRelationship between reticuloendothelial systems' FDG uptake level and clinicopathological features in patient with invasive ductal breast cancer
dc.typeArticle

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