Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study

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dc.authorscopusid58095326300
dc.authorscopusid56868309300
dc.authorscopusid57204592627
dc.authorscopusid58095635300
dc.contributor.authorPolat, E.
dc.contributor.authorÇelik, Ekrem
dc.contributor.authorToğaç, M.
dc.contributor.authorŞahin, A.
dc.date.accessioned2023-05-06T17:22:11Z
dc.date.available2023-05-06T17:22:11Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstract• AIM: To evaluate the effects of metabolic syndrome (MetS) on retinal neurodegeneration by optical coherence tomography (OCT). • METHODS: Patients diagnosed as MetS were compared with the age and sex-matched healthy control group (CG). Waist circumference measurements, fasting serological biochemical tests, and systemic blood pressures of all participants were evaluated. The MetS group was divided into 3 subgroups according to the number of MetS components: hypertension, diabetes mellitus, dyslipidemia (low-, high-density lipoprotein, hypertriglyceridemia), and visceral obesity findings; 3-component MetS3, 4-component MetS4, and all-component MetS5. All patients underwent complete eye examination and spectral OCT retinal imaging. • RESULTS: Totally 58 eyes of 58 patients were included in the MetS group and 63 eyes of 63 age and sex-matched healthy subjects were included in CG. MetS group was composed of 22 subjects in MetS3, 21 subjects in MetS4, and 15 subjects in the MetS5 subgroup. Mean foveal thickness (MetS, 218.7±23.1 µm vs CG, 228.8±21.9 µm, P=0.015), mean inferior (MetS, 283.4±17.0 µm vs CG, 288.7±38.4 µm, P=0.002), superior (MetS, 287.0±18.5 µm vs CG 297.3±17.1 µm, P=0.001), nasal (MetS 287.3±16.7 µm vs CG 297.9±13.9 µm, P=0.000) and temporal (274.5±17.6 µm vs CG 285.6±13.6 µm, P=0.000) thickness in the 3 mm Early Treatment of Diabetic Retinopathy Study (ETDRS) circle was significantly lower in the MetS group. There was no statistically significant difference in the mean inferior, superior, nasal, and temporal thickness of 6 mm ETDRS circle, total macular volume, peripapillary and macular retinal nerve fiber layer, macular ganglion cell layer with inner plexiform layer, and ganglion cell complex. No statistically significant difference was found in these values between the MetS3, MetS4, and the MetS5 groups. • CONCLUSION: A significant reduction in central macular region thickness in MetS is detected and macular thickness is more susceptible to MetS induced neurodegeneration than peripapillary retinal nerve fiber layer. © 2023 International Journal of Ophthalmology (c/o Editorial Office). All rights reserved.
dc.description.sponsorshipAuthors’ contributions: Polat E was responsible for designing the study protocol, supervision the study, conducting the search, screening potentially eligible studies, data collection, updating reference lists, and creating all tables. Celik E was responsible for designing the study protocol, contributed to writing the report, extracting and analyzing data, interpreting results, and creating all tables. Togac M was responsible for writing the protocol and report, contributed to data extraction, and provided feedback on the report. Sahin A was responsible for writing the literature review, data collection.
dc.identifier.doi10.18240/ijo.2023.02.08
dc.identifier.endpage232
dc.identifier.issn2222-3959
dc.identifier.issue2en_US
dc.identifier.pmid36816217
dc.identifier.scopus2-s2.0-85147666160
dc.identifier.scopusqualityQ2
dc.identifier.startpage224
dc.identifier.urihttps://doi.org/10.18240/ijo.2023.02.08
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12098
dc.identifier.volume16
dc.identifier.wosWOS:000994658600008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Ekrem
dc.language.isoen
dc.publisherInternational Journal of Ophthalmology (c/o Editorial Office)
dc.relation.ispartofInternational Journal of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdiabetes mellitus
dc.subjectdyslipidemia
dc.subjecthypertension
dc.subjectmetabolic syndrome
dc.subjectoptical coherence tomography
dc.subjectretinal neurodegeneration
dc.titleRetinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study
dc.typeArticle

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