Breast cancer in young and very young women; Is age related to outcome?

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dc.authorscopusid56082620300
dc.authorscopusid57222993248
dc.authorscopusid57218822513
dc.authorscopusid8666331800
dc.contributor.authorAvcı, Okan
dc.contributor.authorTacar, Seher Yıldız
dc.contributor.authorSeber, Erdoğan Selcuk
dc.contributor.authorYetişyiğit, Tarkan
dc.date.accessioned2022-05-11T14:40:56Z
dc.date.available2022-05-11T14:40:56Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractBackground: Breast cancer in young women is associated with aggressive biology. We analyzed histopathological and clinical properties of breast cancer patients diagnosed at <= 40 years of age. Methods: Breast cancer patients who were admitted between 2015 and 2019 were included. Baseline characteristics of the patients with treatment-related outcomes were assessed. The study group was divided into two subgroups; <35 years old as very young and >= 35 years old as young. Results: The data of 137 patients (60 patients <35 years) were reviewed. The mean age was 34.7 years. The mean follow-up duration was 44.45 +/- 26.39 months, and the mean disease-free survival was 36.17 +/- 21.97 months. 11.4% of the patients were diagnosed with Stage 4 disease. Pathologic subtype was invasive ductal carcinoma in 86% of patients. 16.8% of the patients were luminal A, 38.7% luminal B, 30.5% were human epidermal growth factor receptor-2-positive type, and 15.3% were triple-negative. Only 5 (3.3%) patients had given birth after chemotherapy. During the follow-up period of early-staged diagnosed patients, metastatic disease occurred in 24.6%. The rate of distant metastasis development was statistically higher in the very young group (31% vs. 11%; P = 0.004). Thirteen patients (10.7%) died due to disease progression. Thirty-seven percent of the patients had a positive family history for either breast or ovarian cancer. Conclusions: Very young breast cancer patients seem to have a more aggressive disease course. The low rate of childbearing in this young patient population is conspicuous. An interdisciplinary approach for the management of this special patient population should be taken into consideration.
dc.identifier.doi10.4103/jcrt.JCRT_545_20
dc.identifier.endpage1327
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue6en_US
dc.identifier.pmid34916360
dc.identifier.scopus2-s2.0-85121912543
dc.identifier.scopusqualityQ3
dc.identifier.startpage1322
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_545_20
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8983
dc.identifier.volume17
dc.identifier.wosWOS:000754558000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAvcı, Okan
dc.institutionauthorTacar, Seher Yıldız
dc.institutionauthorSeber, Erdoğan Selcuk
dc.institutionauthorYetişyiğit, Tarkan
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast cancer
dc.subjectfertility
dc.subjectmolecular subtypes
dc.subjectprognosis
dc.subjectyoung age
dc.subjectClinicopathological Features
dc.subjectDiagnosis
dc.titleBreast cancer in young and very young women; Is age related to outcome?
dc.typeArticle

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