Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer

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dc.authoridCan Trabulus, Didem/0000-0003-1687-715X
dc.authoridGUVEN, MEHMET/0000-0002-8749-1708
dc.authoridOzoran, Emre/0000-0002-9371-6811
dc.authorwosidOzoran, Emre/AAM-5091-2020
dc.contributor.authorÖzoran, Emre
dc.contributor.authorTrabulus, Fadime Didem Can
dc.contributor.authorErhan, Duygu
dc.contributor.authorBatar, Bahadır
dc.contributor.authorGüven, Mehmet
dc.date.accessioned2023-04-20T08:01:20Z
dc.date.available2023-04-20T08:01:20Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractBackground. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394) T (rs6869366) DNA repair and BAX G(-248) A (rs4645878), and BCL2 C(-938) A (rs2279115) apoptotic gene polymorphisms with breast cancer. Materials and Methods. Genetic analysis was performed using peripheral blood samples. Gene polymorphisms were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. 175 patients and 158 healthy controls were enrolled in the study. Results. Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248) A (rs4645878) (P=0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. The risk of breast cancer was 2.77 times more in individuals carrying the Met/Met genotype of XRCC3 Thr241Met (rs861539) (P=0.009). The risk of having advanced clinical stage (stage III+IV) with the Met/Met genotype was 4 times more increased. No relationship with breast cancer was found with XRCC4 G(-1394) T (rs6869366) and BCL2 C(-938) A (rs2279115) gene polymorphisms. Conclusion. Multicenter trials using subjects with genetic variations are needed to establish the relationship between breast cancer and single gene polymorphism.
dc.description.sponsorshipsurgery residency thesis by Istanbul Training and Research Hospital; Istanbul Education & Research Hospital as part of a residency thesis
dc.description.sponsorshipAcknowledgments This work was supported as part of a surgery residency thesis by Istanbul Training and Research Hospital. This research has been funded by Istanbul Education & Research Hospital as part of a residency thesis.
dc.identifier.doi10.1155/2022/5817841
dc.identifier.issn2090-3170
dc.identifier.issn2090-3189
dc.identifier.pmid35320970
dc.identifier.scopus2-s2.0-85127477446
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1155/2022/5817841
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10877
dc.identifier.volume2022
dc.identifier.wosWOS:000783666400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBatar, Bahadır
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofInternational Journal of Breast Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSingle-Nucleotide Polymorphisms
dc.subjectEndothelial Growth-Factor
dc.subjectSquamous-Cell Carcinoma
dc.subjectRepair Genes Xrcc1
dc.subjectExpression
dc.subjectSusceptibility
dc.subjectProtein
dc.subjectFamily
dc.subjectImpact
dc.titleAssociation of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer
dc.typeArticle

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