Comparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study

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dc.contributor.authorKaraca, Gamze Tanan
dc.contributor.authorDuygu, Gonca
dc.contributor.authorEr, Nilay
dc.contributor.authorOzgun, Eray
dc.date.accessioned2024-10-29T17:59:23Z
dc.date.available2024-10-29T17:59:23Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThis study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-& alpha;) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.
dc.description.sponsorshipTrakya University Scientific Research Projects Department [2019/235]
dc.description.sponsorshipThis study was funded by the Trakya University Scientific Research Projects Department by the number 2019/235.
dc.identifier.doi10.3390/jcm12134250
dc.identifier.issn2077-0383
dc.identifier.issue13en_US
dc.identifier.pmid37445285
dc.identifier.scopus2-s2.0-85165020166
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm12134250
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14718
dc.identifier.volume12
dc.identifier.wosWOS:001028570300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanti-inflammatory effect
dc.subjectedema
dc.subjectserum markers
dc.subjectPRF
dc.subjectwisdom tooth
dc.titleComparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study
dc.typeArticle

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