PD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer

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dc.authorscopusid57209502497
dc.authorscopusid6602418279
dc.authorscopusid56462867500
dc.authorscopusid54416941500
dc.contributor.authorZengin, Mehmet
dc.contributor.authorZergeroğlu, Sema
dc.contributor.authorOkcu, Oğuzhan
dc.contributor.authorBenek, Suat
dc.date.accessioned2022-05-11T14:04:54Z
dc.date.available2022-05-11T14:04:54Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: Immune responses have long been an area of interest in cancer research. In this study, the effects of programmed cell death-1 (PD-1) and its ligand (PD-L2) on the prognosis of colorectal cancer (CRC) were investigated. Methods: Primary tumour specimens of stage III CRC patients operated between 2002 and 2013 were assessed for PD-1 and PD-L2 expression and various clinicopathological and prognostic factors. Results: We observed a significant relationship between poor prognostic factors and PD-1/PD-L2 expression. These biomarkers were also found to serve as independent risk factors for LIR and MSI. In univariate analysis, relapse-free survival (RFS) and overall survival (OS) rates were found to be poor in PD-1 and PD-L2 positive patients. In multivariate analysis, these biomarkers were found to serve as independent poor prognostic factors for RFS and OS. Conclusions: Our data indicate that PD-1 and PD-L2 may serve as independent prognostic survival parameters for CRC patients and may be employed for the design of targeted therapies. © 2021, Springer Nature Switzerland AG.
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Kırıkkale University.
dc.identifier.doi10.1007/s13402-020-00579-5
dc.identifier.endpage432
dc.identifier.issn2211-3428
dc.identifier.issue2en_US
dc.identifier.pmid33469839
dc.identifier.scopus2-s2.0-85100021704
dc.identifier.scopusqualityQ1
dc.identifier.startpage423
dc.identifier.urihttps://doi.org/10.1007/s13402-020-00579-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4831
dc.identifier.volume44
dc.identifier.wosWOS:000608965100003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBenek, Suat
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofCellular Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColorectal cancer
dc.subjectPD-1
dc.subjectPDL-2
dc.subjectPrognostic biomarkers
dc.subjectStage III
dc.subjectmismatch repair protein
dc.subjectprogrammed death 1 ligand 1
dc.subjectprogrammed death 1 ligand 2
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer patient
dc.subjectcancer recurrence
dc.subjectcancer risk
dc.subjectcancer staging
dc.subjectcancer survival
dc.subjectclinical assessment
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmune response
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicrosatellite instability
dc.subjectmicroscopy
dc.subjectoverall survival
dc.subjectprimary tumor
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrecurrence free survival
dc.subjectrelapse
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsurgical margin
dc.subjecttumor microenvironment
dc.titlePD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer
dc.typeArticle

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