The Real-World Experience With Single Agent Ibrutinib in Relapsed/Refractory CLL
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction/Background: The emergence of novel agents targeting the B-cell receptor pathway and BCL-2 has significantly changed the therapeutic landscape of CLL. We evaluated the safety and efficacy of single-agent ibrutinib in relapsed/refractory CLL in real-world settings. Patients/Methods: A total of 200 relapsed/refractory CLL patients with a median age of 68 were included in this retrospective, multicenter, non-interventional study. Data of the study were captured from the patient charts of the participating centers. Results: The median for lines of previous chemotherapy was 2 (1-6); 62 (31.8%) patients had del17p and/or p53 mutations (del17p+/p53mut). Of the study group, 146 (75%) patients achieved at least PR, while 16 (8.7%) patients discontinued ibrutinib due to TEA. The most common drug-related adverse events were neutropenia (n: 31; 17.4%) and thrombocytopenia (n: 40; 22.3%), which were ? grade 3 in 9 (5%) and 5 (3.9%) patients, respectively. Pneumonia (n: 42; 23.7%) was the most common nonhematologic TEA. Atrial fibrillation (n: 5; 2.8%) and bleeding (n: 11; 6.3%) were relatively rare during the study period. Within a median follow-up period of 17 (1-74) months, 42 (21%) patients died. The estimated median OS of the study cohort was 52 months. Only the response to ibrutinib (CR/PR vs. SD/PD) was significantly associated with OS. Conclusion: Our results indicate good safety and efficacy for single-agent ibrutinib in R/R CLL in daily practice. © 2021 Elsevier Inc.
Açıklama
Anahtar Kelimeler
Bruton tyrosine kinase, Chronic lymphocytic leukemia, Ibrutinib, p53 mutation, Relapsed/refractory, ibrutinib, adult, aged, Article, atrial fibrillation, bleeding, cancer recurrence, cancer staging, chronic lymphatic leukemia, cohort analysis, comparative study, controlled study, cytogenetics, demography, drug efficacy, drug safety, drug tolerability, female, follow up, human, hypertension, leukemia relapse, major clinical study, male, multicenter study, multicenter study (topic), neutropenia, overall survival, pneumonia, retrospective study, thrombocytopenia, treatment response
Kaynak
Clinical Lymphoma, Myeloma and Leukemia
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
22
Sayı
3
