Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome

Basit Öğe Kaydı
dc.authorid0000-0002-5770-344X
dc.authorid0000-0002-8892-0439
dc.authorscopusid34876196800
dc.authorscopusid29067508300
dc.authorscopusid27967486000
dc.authorscopusid7003436663
dc.authorscopusid55891056300
dc.authorscopusid55365316700
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidHashimoto, Kenji/I-5800-2015
dc.contributor.authorAkyol, Esra Soydaş
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorAksoy, Nurkan
dc.contributor.authorKuloğlu, Murat
dc.contributor.authorHashimoto, Kenji
dc.date.accessioned2022-05-11T14:41:05Z
dc.date.available2022-05-11T14:41:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Brain-derived neurotrophic factor (BDNF) is a well-established neurotrophin that plays a role in the pathophysiology of numerous psychiatric disorders. Many studies have investigated the serum BDNF levels in patients with schizophrenia. However, there are restricted data in the literature that compare the serum BDNF levels in patients with deficit and nondeficit syndromes. In this study, we aimed to compare the serum BDNF levels between schizophrenic patients with deficit or nondeficit syndrome and healthy controls. Methods: After fulfilling the inclusion and exclusion criteria, 58 patients with schizophrenia and 36 healthy controls were included in the study. The patients were grouped as deficit syndrome (N=23) and nondeficit syndrome (N=35) according to the Schedule for the Deficit Syndrome. Three groups were compared in terms of the sociodemographic and clinical variants and serum BDNF levels. Results: The groups were similar in terms of age, sex, body mass index, and smoking status. The serum BDNF levels in patients with deficit syndrome were significantly lower than those in healthy controls. In contrast, the serum BDNF levels in patients with nondeficit syndrome were similar to those in healthy controls. Conclusion: This study suggests that decreased BDNF levels may play a role in the pathophysiology of schizophrenic patients with deficit syndrome. Nonetheless, additional studies using a larger patient sample size are needed to investigate the serum BDNF levels in schizophrenic patients with deficit syndrome.
dc.identifier.doi10.2147/NDT.S79444
dc.identifier.endpage872
dc.identifier.issn1178-2021
dc.identifier.pmid25848285
dc.identifier.scopus2-s2.0-84929168081
dc.identifier.scopusqualityQ2
dc.identifier.startpage865
dc.identifier.urihttps://doi.org/10.2147/NDT.S79444
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9056
dc.identifier.volume11
dc.identifier.wosWOS:000351855500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomarker
dc.subjectneurotrophin
dc.subjectpsychosis
dc.subjectBdnf Levels
dc.subjectAtypical Antipsychotics
dc.subjectTardive-Dyskinesia
dc.subjectBipolar Disorder
dc.subjectDisease
dc.subjectPlasma
dc.subjectMetalloproteinases
dc.subjectPotentiation
dc.subjectModulation
dc.subjectDepression
dc.titleDecreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
9056.pdf
Boyut:
563.5 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu