Determining the Risk Factors for Anastomotic Stricture Development after Esophageal Atresia Repair: Results from the Turkish Esophageal Atresia Registry

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dc.authoridOZTAN, Mustafa Onur/0000-0003-3696-4090
dc.authoridOzcan, Rahsan/0000-0002-8873-2841
dc.authoridSoyer, Tutku/0000-0003-1505-6042
dc.authoridOZTORUN, CAN IHSAN/0000-0002-5408-2772
dc.contributor.authorOztorun, Can Ihsan
dc.contributor.authorDurakbasa, Cigdem Ulukaya
dc.contributor.authorSoyer, Tutku
dc.contributor.authorOzcan, Coskun
dc.contributor.authorFirinci, Binali
dc.contributor.authorDemirel, Berat Dilek
dc.contributor.authorCiftci, Ilhan
dc.date.accessioned2024-10-29T17:58:33Z
dc.date.available2024-10-29T17:58:33Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIntroduction Anastomotic stricture (AS) is the second most common complication after esophageal atresia (EA) repair. We aimed to evaluate the data in the Turkish Esophageal Atresia Registry to determine the risk factors for AS development after EA repair in a large national cohort of patients. Methods The data between 2015 and 2021 were evaluated. Patients were enrolled into two groups according to the occurrence of AS. Patients with AS (AS group) and without AS (non-AS group) were compared according to demographic and operative features, postoperative intubation status, and postoperative complications, such as anastomotic leaks, fistula recanalization, and the presence of gastroesophageal reflux (GER). A multivariable logistic regression analysis was performed to define the risk factors for the development of AS after EA repair. Results Among the 713 cases, 144 patients (20.19%) were enrolled into the AS group and 569 (79.81%) in the non-AS group. The multivariable logistic regression showed that, being a term baby (odds ratio [OR]: 1.706; p = 0.006), having a birth weight over 2,500 g (OR: 1.72; p = 0.006), presence of GER (OR: 5.267; p < 0.001), or having a recurrent tracheoesophageal fistula (TEF, OR: 4.363; p = 0.006) were the risk factors for the development of AS. Conclusions The results of our national registry demonstrate that 20% of EA patients developed AS within their first year of life. In patients with early primary anastomosis, birth weight greater than 2,500 g and presence of GER were risk factors for developing AS. When patients with delayed anastomosis were included, in addition to the previous risk factors, being a term baby, and having recurrent TEF also became risk factors.
dc.identifier.doi10.1055/a-2340-9078
dc.identifier.issn0939-7248
dc.identifier.issn1439-359X
dc.identifier.pmid38848757
dc.identifier.scopus2-s2.0-85196408848
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1055/a-2340-9078
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14388
dc.identifier.wosWOS:001258378300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofEuropean Journal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectesophageal atresia
dc.subjecttracheoesophageal fistula
dc.subjectanastomotic strictures
dc.subjectrisk factors
dc.titleDetermining the Risk Factors for Anastomotic Stricture Development after Esophageal Atresia Repair: Results from the Turkish Esophageal Atresia Registry
dc.typeArticle

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