Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients

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dc.authorscopusid26532378600
dc.authorscopusid16315021800
dc.authorscopusid6505680586
dc.authorscopusid7102765266
dc.authorscopusid56503950500
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAydın, Murat
dc.contributor.authorErselcan, Kubilay
dc.date.accessioned2022-05-11T14:14:04Z
dc.date.available2022-05-11T14:14:04Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective Cardiovascular diseases are more common in patients with nondipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The aim of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients. Methods The study population included newly diagnosed hypertensive patients who were not under antihypertensive treatment. A total of 77 patients were evaluated with ambulatory blood pressure monitoring and divided into two groups: NDHT (n = 42) and DHT (n = 35). Plasma neurokinin B levels were measured using the ELISA method. Results Serum neurokinin B levels were significantly higher in the NDHT group compared with the DHT group [254 (180-888) and 207 (116-752) pg/ml, respectively; P = 0.024]. There is a positive correlation between the mean night-time systolic blood pressure and plasma neurokinin levels (r = 0.590; P < 0.001). On regression analysis, neurokinin B level was only found to be related to the mean night-time systolic blood pressure (unstandardized beta = -22.02 +/- 9.59; P < 0.001). Conclusion Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. There is a need for further studies that search for the relation between serum neurokinin B levels and NDHT. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
dc.identifier.doi10.1097/MBP.0000000000000108
dc.identifier.endpage149
dc.identifier.issn1359-5237
dc.identifier.issn1473-5725
dc.identifier.issue3en_US
dc.identifier.pmid25647283
dc.identifier.scopus2-s2.0-84955387401
dc.identifier.scopusqualityQ2
dc.identifier.startpage144
dc.identifier.urihttps://doi.org/10.1097/MBP.0000000000000108
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5770
dc.identifier.volume20
dc.identifier.wosWOS:000354105600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkkoyun, Dursun Ceyhan
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAydın, Murat
dc.institutionauthorErselcan, Kubilay
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Pressure Monitoring
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectblood pressure
dc.subjectdipper
dc.subjecthypertension
dc.subjectneurokinin B
dc.subjectnondipper
dc.subjectBlood-Pressure
dc.subjectEuropean-Association
dc.subjectTachykinin
dc.subjectDisease
dc.subjectIncreases
dc.titleSerum neurokinin B levels in newly diagnosed nondipper hypertensive patients
dc.typeArticle

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