The Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease

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dc.authorid0000-0002-4641-962X
dc.authorid0000-0003-2112-4056
dc.authorscopusid56715752200
dc.authorscopusid54892706700
dc.authorscopusid7102765266
dc.authorscopusid55881189500
dc.authorscopusid16025413500
dc.authorscopusid12772417700
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorBilir, Bülent
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorAydın, Murat
dc.contributor.authorOran, Mustafa
dc.contributor.authorÖzsu, Savaş
dc.contributor.authorTutar, Umit
dc.date.accessioned2022-05-11T14:10:14Z
dc.date.available2022-05-11T14:10:14Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Recently neutrophil-to-lymphocyte ratio (NLR) -the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status. In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated. Method: We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people. C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cut-off value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant. Results: By spearman analysis, there was a strong correlation between. C-Reactive protein and N/L ratio in both stable group (r=0.436, p<0.001) and exacerbation group (r=0.534, p=0.001). Conclusion: Neutrophil/lymphocyte ratio may be a useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.
dc.identifier.doi10.15197/ejgm.1554
dc.identifier.endpage110
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84963997986
dc.identifier.scopusqualityN/A
dc.identifier.startpage105
dc.identifier.urihttps://doi.org/10.15197/ejgm.1554
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5337
dc.identifier.volume13
dc.identifier.wosWOS:000392237800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBilir, Bülent
dc.institutionauthorOran, Mustafa
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorAydın, Murat
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute exacerbation
dc.subjectchronic obstructive pulmonary disease
dc.subjectneutrophil-to-lymphocyte ratio
dc.subjectCopd
dc.subjectExacerbations
dc.subjectInflammation
dc.subjectMortality
dc.subjectBurden
dc.titleThe Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease
dc.title.alternativeKronik obstrüktif akciğer hastalığında nötrofil-lenfosit oranının öngörücü rolü]
dc.typeArticle

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