Oxidative stress in neonatal lambs and its relation to health status and passive colostral immunity

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dc.authorscopusid25635201400
dc.authorscopusid56539994200
dc.authorscopusid8545293300
dc.authorscopusid6506426943
dc.authorscopusid7006831790
dc.contributor.authorGökçe, Erhan
dc.contributor.authorCihan, Pınar
dc.contributor.authorAtakişi, Onur
dc.contributor.authorKırmızıgül, Ali Haydar
dc.contributor.authorErdoğ, Hidayet Metin
dc.date.accessioned2023-04-20T08:01:14Z
dc.date.available2023-04-20T08:01:14Z
dc.date.issued2022
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractOxidative stress (OS) related to birth in ruminants may increase susceptibility to diseases. However, information about the physiological changes related to OS in lambs is limited. This study was designed to evaluate changes in OS parameters [total antioxidant status (TAS, mmol Trolox Equiv./L), total oxidant status (TOS, mu mol H2O2 Equiv./L)] and calculated oxidative stress index (OSi = TOS/TAS * 100, Arbitrary Unit) and its association with passive colostral transfer immunity and health status in neonatal Akkaraman crossbreed lambs. Control group of healthy lambs (n = 15) were blood sampled before (day 0) and after colostrum intake (on day 1, 2, 4, 7, 14 and 28) in order to evaluate the effect of colostrum intake on TAS, TOS and OSi over time. In addition, a group of lambs (experimental group, n = 60), based on their health status and different cut off value of IgG (mg/dL), was also blood sampled at 24 & PLUSMN; 1 h of colostrum ingestion to determine the relationship between OS parameters, IgG and health status. OS was evident at birth and gradually decreased in control group as TOS (days 0:8.06 & PLUSMN; 0.64, 1:7.05 +/- 0.51, 2:5.23 +/- 0.35, 4:5.05 & PLUSMN; 0.2, 7:5.13 v 0.34, 14:3.75 +/- 0.12 and 28:3.73 & PLUSMN; 0.15 mu mol H2O2 Equiv./L), OSi (days 0: 8.35 +/- 0.64, 1: 9.17 +/- 1.05, 2:6.83 +/- 0.6, 4:6.30 & PLUSMN; 0.20, 7:6.67 +/- 0.59, 14:4.46 & PLUSMN; 0.19 and 28:4.87 +/- 0.29 au) and TAS (days 0: 0.97 & PLUSMN; 0.02, 1:0.82 +/- 0.04, 2:0.81 +/- 0.05, 4:0.81 +/- 0.02, 7:0.80 +/- 0.03, 14:0.85 +/- 0.02 and 28:0.79 +/- 0.03 mmol Trolox Equiv./L) values changed over time. In the experimental group, the lambs died in the first week of the neonatal period had higher levels of TOS (10.3 +/- 0.90 mu mol H2O2 Equiv./L) and OSi (1.61 +/- 0.22 au) than healthy ones (TOS:6.90 +/- 0.36 mu mol HO2 Equiv./L, OSi:1.12 & PLUSMN; 0.11 au) (P < 0.001). The gradual decrease in OS in the neonatal period was accepted as a sign of improved antioxidant response. The study disclosed that deaths may develop when OS at birth is not balanced by sufficient amount and quality of colostrum an important source of antioxidants such as enzymes and vitamins. The study presented may provide new in-formation in the field of study on oxidative stress in neonatal lambs and help to prevent deaths in the first week of life. It can also be useful in developing preventive measures such as supplements of antioxidants to colostrum.
dc.description.sponsorshipScientific and Technological Research Council of T?rkiye (TUBITAK) [TOVAG 108 O 847]; Scientific Research Projects Coordination Unit of Kafkas University [2010 -VF -04]
dc.description.sponsorshipFunding This work was supported by The Scientific and Technological Research Council of T?rkiye (TUBITAK) (Project no.: TOVAG 108 O 847) and the Scientific Research Projects Coordination Unit of Kafkas University (Grant no. 2010 -VF -04) .
dc.identifier.doi10.1016/j.vetimm.2022.110470
dc.identifier.issn0165-2427
dc.identifier.issn1873-2534
dc.identifier.pmid35985179
dc.identifier.scopus2-s2.0-85135876178
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.vetimm.2022.110470
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10816
dc.identifier.volume251
dc.identifier.wosWOS:000844022800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCihan, Pınar
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofVeterinary Immunology and Immunopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeonatal Lamb
dc.subjectPassive Immunity
dc.subjectTos
dc.subjectTas
dc.subjectOsi
dc.subjectTotal Antioxidant Capacity
dc.subjectLipid-Peroxidation
dc.subjectSerum Lactoferrin
dc.subjectIgg Concentration
dc.subjectDairy Calves
dc.subjectRedox Status
dc.subjectSheep
dc.subjectBirth
dc.subjectBlood
dc.subjectCows
dc.titleOxidative stress in neonatal lambs and its relation to health status and passive colostral immunity
dc.typeArticle

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