Indices Used in Differentiation of Thalassemia Trait from Iron Deficiency Anemia in Pediatric Population: Are They Reliable?

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dc.authorid0000-0001-5992-9488
dc.authorid0000-0002-4060-0583
dc.authorid0000-0002-5630-3399
dc.authorscopusid36165893600
dc.authorscopusid23968920100
dc.authorscopusid55332181500
dc.authorscopusid6601976056
dc.authorscopusid42661653300
dc.authorscopusid54791156900
dc.authorscopusid55332236300
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidNALBANTOGLU, BURCIN/A-5386-2018
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.contributor.authorNalbanto?lu, Burçin
dc.contributor.authorGüzel, Savaş
dc.contributor.authorBüyükyalçın, Volkan
dc.contributor.authorDonma, Mustafa Metin
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorNalbantoğlu, Ayşin
dc.contributor.authorÖzdilek, Burcu
dc.date.accessioned2022-05-11T14:14:02Z
dc.date.available2022-05-11T14:14:02Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the pediatric age group are scarce and their results are controversial. Methods: We calculated eight discrimination indices [Mentzer Index (MI), England and Fraser Index (E&F), Srivastava Index (S), Green and King Index (G&K), Shine and Lal Index (S&L), red blood cell (RBC) count, RBC distribution width, and red blood cell distribution width Index (RDWI)] in 100 patients. We calculated sensitivity (SENS), specificity (SPEC), positive and negative predictive value (PPV and NPV), and Youden's Index (YI) of each discrimination index. Results: None of the discrimination indices showed a SENS and SPEC of 100%. The highest SENS was obtained with S&L (87.1%), while the highest SPEC was obtained with E&F formula (100%). The highest YI value was obtained with E&F formula (58.1%). Conclusion: In our study, none of the formulas appears reliable in discriminating between TT and IDA patients. The evaluation of iron status and measurement of hemoglobin A(2) (HbA(2)) remain the most reliable investigations to differentiate between TT and IDA patients.
dc.identifier.doi10.3109/08880018.2012.705230
dc.identifier.endpage478
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue5en_US
dc.identifier.pmid22866672
dc.identifier.scopus2-s2.0-84864862387
dc.identifier.scopusqualityQ3
dc.identifier.startpage472
dc.identifier.urihttps://doi.org/10.3109/08880018.2012.705230
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5756
dc.identifier.volume29
dc.identifier.wosWOS:000307184400010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNalbanto?lu, Burçin
dc.institutionauthorGüzel, Savaş
dc.institutionauthorBüyükyalçın, Volkan
dc.institutionauthorDonma, Mustafa Metin
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorNalbantoğlu, Ayşin
dc.institutionauthorÖzdilek, Burcu
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofPediatric Hematology and Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanemia
dc.subjectdiagnosis
dc.subjectdifferential
dc.subjectiron deficiency
dc.subjectthalassemia
dc.subjectBeta-Thalassemia
dc.subjectDiscrimination Indexes
dc.subjectScreening-Tests
dc.subjectParameters
dc.subjectFormulas
dc.subjectReliability
dc.subjectDiagnosis
dc.subjectVolume
dc.titleIndices Used in Differentiation of Thalassemia Trait from Iron Deficiency Anemia in Pediatric Population: Are They Reliable?
dc.typeArticle

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