Antioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats

Basit Öğe Kaydı
dc.authorscopusid36696857400
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid55116304900
dc.authorscopusid6603033479
dc.contributor.authorToydemir, Toygar
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorOğuz, Serhat
dc.contributor.authorErenoğlu, Cengiz
dc.date.accessioned2022-05-11T14:41:27Z
dc.date.available2022-05-11T14:41:27Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH+curcumin; each group contains eight animals. The rats in curcumin-treated groups were given curcumin (in a dose of 100mg/kg body weight) once a day orally for 7days, starting 3days prior to hepatectomy operation. At 7days after resection, liver samples were collected. The malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated 2-deoxyuridine, 5-triphosphate nick end-labeling assay, and apoptotic index (AI) were evaluated at 7days after hepatectomy. As a result, curcumin significantly increased MI and PI and significantly decreased AI in PH rats. Additionally, curcumin remarkably inhibited MDA elevation, restored impaired antioxidant SOD activity and GSH level and also attenuated hepatic vacuolar degeneration and sinusoidal congestion. These results suggested that curcumin treatment had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative, antiapoptotic, and proliferative properties.
dc.identifier.doi10.1177/0748233712469658
dc.identifier.endpage172
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid23299190
dc.identifier.scopus2-s2.0-84921779221
dc.identifier.scopusqualityQ3
dc.identifier.startpage162
dc.identifier.urihttps://doi.org/10.1177/0748233712469658
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9186
dc.identifier.volume31
dc.identifier.wosWOS:000348905300006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectpartial hepatectomy
dc.subjectoxidative stress
dc.subjectimmunohistochemistry
dc.subjectTUNEL
dc.subjectrat
dc.subjectCell Nuclear Antigen
dc.subjectLipid-Peroxidation
dc.subjectHepatocellular-Carcinoma
dc.subjectOxidative Stress
dc.subjectMitochondrial
dc.subjectHepatocytes
dc.subjectInhibition
dc.subjectExpression
dc.subjectApoptosis
dc.subjectNecrosis
dc.titleAntioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
9186.pdf
Boyut:
536.17 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu