Diagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study

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dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authorscopusid57203644941
dc.authorscopusid57218879837
dc.authorscopusid57758162300
dc.authorscopusid57758035200
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorOrun, Serhat
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorBaşol, Batuhan İlbey
dc.contributor.authorYeniay, Elif
dc.date.accessioned2023-04-20T08:01:15Z
dc.date.available2023-04-20T08:01:15Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground This study aims to investigate the diagnostic accuracy of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE). Methods Patients admitted to the emergency department of a tertiary health centre between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with (PE) and compared with that of healthy volunteers. Receiver operating characteristic analysis was performed with the obtained data, and the area under the curve (AUC) with a 95% confidence interval was determined. The parameters of diagnostic accuracy for PE were determined. Results A total of 57 participants were included in the study (28 controls and 29 PE patients). The mean adropin level in the PE group was 187.33 +/- 62.40 pg/ml, which was significantly lower than that in the control group (524.06 +/- 421.68 pg/ml) (p < 0.001). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Conclusion Our results suggest that adropin may be considered for further study as a candidate marker for the exclusion of the diagnosis of PE. However, more research is required to verify and support the generalizability of our study results.
dc.identifier.doi10.1186/s12890-022-02156-y
dc.identifier.issn1471-2466
dc.identifier.issue1en_US
dc.identifier.pmid36115957
dc.identifier.scopus2-s2.0-85138212371
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12890-022-02156-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10830
dc.identifier.volume22
dc.identifier.wosWOS:000854830900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorBaşol, Batuhan İlbey
dc.institutionauthorYeniay, Elif
dc.institutionauthorOrun, Serhat
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Pulmonary Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdropin
dc.subjectBiomarker
dc.subjectEmergency Medicine
dc.subjectAcute Pulmonary Embolism
dc.subjectD-Dimer
dc.subjectComputed-Tomography
dc.subjectPotential Marker
dc.subjectOutpatients
dc.subjectManagement
dc.subjectEmergency
dc.titleDiagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study
dc.typeArticle

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