The role of primary tumor resection in patients with stage IV colorectal cancer with unresectable metastases

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dc.authorscopusid57191612456
dc.authorscopusid54927630300
dc.authorscopusid25624308200
dc.authorscopusid8665552100
dc.authorscopusid57216821314
dc.authorscopusid55402747600
dc.contributor.authorUrvay, Semiha
dc.contributor.authorEren, Tülay
dc.contributor.authorCivelek, Burak
dc.contributor.authorKılıçkap, Sadettin
dc.contributor.authorYetişyiğit, Tarkan
dc.contributor.authorÖzaslan, Ersin
dc.date.accessioned2022-05-11T14:05:05Z
dc.date.available2022-05-11T14:05:05Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractPurpose: Whether primary tumor resection (PTR) should be performed in patients with asymptomatic colorectal cancer (CRC) and unresectable synchronous metastasis is controversial. The purpose of this study was to investigate the prognostic impact of initial primary tumor resection in pa-tients with synchronous unresectable metastatic CRC. Methods: The patients with unresectable synchronous metastatic CRC who had undergone primary tumor resection and then received chemotherapy were compared with the patients who received only palliative systemic chemotherapy. Results: Survival analysis showed that median overall survival (OS) for all patients was 22.37 months. Primary tumor resection was associated with a significant survival benefit on unadjusted analysis (median survival 29.56 months vs. 14.25 months; p<0.001). Two-year, 3-year and 5-year survival rates were 57%, 35%, 19% for the PTR group and 30%, 16%, 8% for the non-PTR group and all results were statistically significant and favored surgery. Conclusions: Our study suggests that primary tumor resection improves the survival of patients with metastatic CRC and unresectable synchronous metastasis. © 2020 Zerbinis Publications. All rights reserved.
dc.identifier.endpage944
dc.identifier.issn1107-0625
dc.identifier.issue2en_US
dc.identifier.pmid32521889
dc.identifier.scopus2-s2.0-85084806057
dc.identifier.scopusqualityQ3
dc.identifier.startpage939
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4889
dc.identifier.volume25
dc.identifier.wosWOS:000562380000021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYetişyiğit, Tarkan
dc.language.isoen
dc.publisherZerbinis Publications
dc.relation.ispartofJournal of B.U.ON.
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemotherapy
dc.subjectMetastatic colorectal cancer
dc.subjectPrimary tumor resection
dc.subjectantineoplastic agent
dc.subjectbevacizumab
dc.subjectcapecitabine plus oxaliplatin
dc.subjectcetuximab
dc.subjectpanitumumab
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer combination chemotherapy
dc.subjectcancer palliative therapy
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectcancer survival
dc.subjectcohort analysis
dc.subjectcomparative study
dc.subjectfemale
dc.subjecthuman
dc.subjectinoperable cancer
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedian survival time
dc.subjectmetastatic colorectal cancer
dc.subjectmultiple cycle treatment
dc.subjectoverall survival
dc.subjectperforation
dc.subjectpostoperative hemorrhage
dc.subjectpostoperative ileus
dc.subjectprimary tumor
dc.subjectprogression free survival
dc.subjectretrospective study
dc.subjectsurgical patient
dc.subjectsurvival analysis
dc.subjectsurvival rate
dc.subjectsystemic therapy
dc.subjectcolorectal tumor
dc.subjectmetastasis
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectprognosis
dc.subjectvery elderly
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectColorectal Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Metastasis
dc.subjectNeoplasm Staging
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectYoung Adult
dc.titleThe role of primary tumor resection in patients with stage IV colorectal cancer with unresectable metastases
dc.typeArticle

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