F-18 FDG PET/CT imaging in the diagnostic work-up of thyroid cancer patients with high serum thyroglobulin, negative I-131 whole body scan and suppressed thyrotropin: 8-year' experience

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dc.authorid0000-0002-3650-8258
dc.authorid0000-0001-5364-1299
dc.authorscopusid50461202500
dc.authorscopusid56957136800
dc.authorscopusid35949526800
dc.authorscopusid54880546000
dc.authorscopusid56725133200
dc.authorscopusid56490954700
dc.authorscopusid57214923299
dc.authorwosidSahin, Ertan/AAG-8999-2020
dc.authorwosidELBOGA, UMUT/AAH-1320-2020
dc.authorwosidÇelen, Yusuf Zeki/AAG-8083-2020
dc.contributor.authorElboğa, Umut
dc.contributor.authorKaraoğlan, H.
dc.contributor.authorŞahin, Ertan
dc.contributor.authorKalender, Ebuzer
dc.contributor.authorDemir, Hasan Deniz
dc.contributor.authorBaşıbüyük, Mustafa
dc.contributor.authorÖzkaya, M.
dc.date.accessioned2022-05-11T14:40:53Z
dc.date.available2022-05-11T14:40:53Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Fluorodeoxyglucose positron emission tomography/computed tomography imaging in the follow-up of patients with differentiated thyroid carcinoma who have high serum thyroglobulin, negative iodine-131 whole body scan and suppressed thyrotropin. PATIENTS AND METHODS: A total of 90 patients (31 male and 59 female) with differentiated thyroid carcinoma who have high serum thyroglobulin and negative iodine-131 whole body scan were included in the study between July 2006 and March 2014. All patients had undergone surgery (total thyroidectomy +/- lymph node dissection) followed by iodine-131 ablation. Of the patients, 82 had papillary thyroid carcinoma and 8 follicular thyroid carcinoma. Serum thyrotropin was suppressed (< 2 mu IU/ml) during the Fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging procedure. RESULTS: The overall sensitivity of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in the detection of metastasis of differentiated thyroid cancer was 84.8%, the specificity 79.1%, respectively. The sensitivity and specificity of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in classic type of papillary cancer was 83.3% and 54.5%, respectively. The corresponding figures for the tall cell variant was 85.7% and 87.5%, respectively. The difference between the two histological subtypes was statistically significant (p < 0.05). CONCLUSIONS: Our results suggest that fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging could be a valuable test for the routine follow-up of patients with differentiated thyroid carcinoma.
dc.identifier.endpage401
dc.identifier.issn1128-3602
dc.identifier.issue3en_US
dc.identifier.pmid25720709
dc.identifier.scopus2-s2.0-84941094820
dc.identifier.scopusqualityQ2
dc.identifier.startpage396
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8953
dc.identifier.volume19
dc.identifier.wosWOS:000351491800012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Ertan
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThyroid neoplasms
dc.subjectWhole body imaging
dc.subjectPositron emission tomography
dc.subjectThyroglobulin
dc.subjectPositron-Emission-Tomography
dc.subjectElevated Thyroglobulin
dc.subjectFollow-Up
dc.subjectCarcinoma
dc.subjectMetastases
dc.subjectImpact
dc.subjectPapillary
dc.titleF-18 FDG PET/CT imaging in the diagnostic work-up of thyroid cancer patients with high serum thyroglobulin, negative I-131 whole body scan and suppressed thyrotropin: 8-year' experience
dc.typeArticle

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