Increased serum dehydroepiandrosterone sulfate in the first episode but not in subsequent episodes in male patients with schizophrenia

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dc.authorid0000-0002-5770-344X
dc.authorid0000-0001-5680-0101
dc.authorscopusid27967486000
dc.authorscopusid29067508300
dc.authorscopusid55773915300
dc.authorscopusid26432848600
dc.authorscopusid27967606700
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidBEYAZYÜZ, Elmas/ABA-7951-2020
dc.authorwosidGöka, Erol/AAC-9757-2019
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorBeyazyüz, Elmas
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorGoka, Erol
dc.date.accessioned2022-05-11T14:41:04Z
dc.date.available2022-05-11T14:41:04Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Many studies have investigated the relationship between blood levels of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S), cortisol, progesterone, and testosterone and the onset, prognosis, symptom severity, and treatment response of schizophrenia. In the present study, we assessed potential differences in blood levels of neurosteroids between drug-naive first-episode patients with schizophrenia (FES), and drug-free patients with schizophrenia who were not in the first episode but were in a phase of acute exacerbation (DFP). Materials and methods: The present study included 32 male FES, 28 male DFP, and 24 male healthy controls (HC). Groups were compared in terms of blood levels of adrenocorticotropic hormone (ACTH), cortisol, testosterone, progesterone, and DHEA-S. Results: Blood levels of ACTH, cortisol, testosterone, and progesterone were similar among the groups. The mean value of serum DHEA-S was significantly different among the groups (P<0.001). The value of serum DHEA-S was higher in the FES group than in the DFP and HC groups (both P<0.001). The mean values of serum DHEA-S in the HC and DFP groups were found to be similar (P=0.33). Conclusion: We suggest that higher values of DHEA-S in the FES group compared with both the DFP and HC groups indicate that this neurosteroid response is unique to first-episode schizophrenia patients. Further studies are needed to investigate the difference in blood levels of neurosteroids in different groups in terms of age of diagnosis.
dc.identifier.doi10.2147/NDT.S61406
dc.identifier.endpage693
dc.identifier.issn1178-2021
dc.identifier.pmid24812513
dc.identifier.scopus2-s2.0-84899706731
dc.identifier.scopusqualityQ2
dc.identifier.startpage687
dc.identifier.urihttps://doi.org/10.2147/NDT.S61406
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9052
dc.identifier.volume10
dc.identifier.wosWOS:000335314000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorÜnsal, Cüneyt
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectneurosteroid
dc.subjecteffect
dc.subjectpsychosis
dc.subjectPosttraumatic-Stress-Disorder
dc.subjectNeuroactive Steroids
dc.subjectNegative Symptoms
dc.subjectCortisol
dc.subjectMechanisms
dc.subjectLevel
dc.subjectDhea
dc.subjectAndrogens
dc.subjectSeverity
dc.subjectCytokine
dc.titleIncreased serum dehydroepiandrosterone sulfate in the first episode but not in subsequent episodes in male patients with schizophrenia
dc.typeArticle

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