Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

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dc.authorid0000-0002-2270-2965
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorOran, Mustafa
dc.contributor.authorTülübaş, Feti
dc.contributor.authorMete, Rafet
dc.contributor.authorAydın, Murat
dc.contributor.authorYıldız, Zeynep Deniz
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:14:03Z
dc.date.available2022-05-11T14:14:03Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractMany bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link, serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6+/-7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 +/- 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p> 0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals.
dc.identifier.doi10.15197/ejgm.01383
dc.identifier.endpage198
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84941552858
dc.identifier.scopusqualityN/A
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.15197/ejgm.01383
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5763
dc.identifier.volume12
dc.identifier.wosWOS:000367542600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorOran, Mustafa
dc.institutionauthorTülübaş, Feti
dc.institutionauthorMete, Rafet
dc.institutionauthorAydın, Murat
dc.institutionauthorYıldız, Zeynep Deniz
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIron deficiency anaemia
dc.subjectmacrophage migration inhibitory factor
dc.subjectmonocyte chemoattractant protein-1
dc.subjectNecrosis-Factor-Alpha
dc.subjectImmune-Response
dc.subjectCytokine Production
dc.titleIron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1
dc.typeArticle

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