Determination of the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-? (TNF-?) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats

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dc.contributor.authorAras, Şükran
dc.contributor.authorKılıcle, Pınar Aksu
dc.contributor.authorYıldız, Sevda Eliş
dc.contributor.authorUluman, Erhan
dc.contributor.authorBakır, Buket
dc.contributor.authorSarı, Ebru Karadağ
dc.contributor.authorDag, Serpil
dc.date.accessioned2024-10-29T17:55:41Z
dc.date.available2024-10-29T17:55:41Z
dc.date.issued2022
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: This study aimed to investigate the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-? (TNF-?) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats. Material and Method: Experimental groups were created as control, sham, chia, dandelion, diabetes (DM), diabetes+chia (DC), and diabetes +dandelion (DD). Body weight and blood glucose measurements were taken on the 1st, 3rd, and 17th days of the study and evaluated statistically. A one-way ANOVA test was performed to determine the differences between the groups. The Duncan test was used to compare significant differences between groups. At the end of the study, Masson's trichrome staining and Hematoxylin-Eosin staining were employed for histological examinations of liver tissues, and the distribution of TNF-? and IL-6 was examined by applying the Streptavidin-biotin peroxidase method. Results: It was determined that body weight and blood glucose measurements were significantly decrease for the DC group compared to other groups. Immunoreactivity of TNF-? and IL-6 was found to decrease in DC and DD groups at close to the control levels. Conclusion: Based on our results, it was thought that the use of chia and dandelion in diabetes may contribute to the alleviation of disease-related complications by having a positive effect on proinflammatory cytokine levels.
dc.identifier.endpage52
dc.identifier.issn2602-3695
dc.identifier.issue2en_US
dc.identifier.startpage43
dc.identifier.trdizinid1164737
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1164737
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14140
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Veterinary Research (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChia
dc.subjectDiabetes mellitus
dc.subjectTNF-?
dc.subjectIL-6
dc.subjectDandelion
dc.titleDetermination of the effects of Chia (Salvia hispanica L.) oil and Dandelion (Taraxacum Officinale) extract on Tumor Necrosis Factor-? (TNF-?) and Interleukin 6 (IL-6) release in liver tissue of diabetic rats
dc.typeArticle

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