The Atrophy of the Vagus Nerve Correlated With Gastrointestinal Non-Motor Symptoms Scores, in Parkinson's Disease: A Sonography Research Study

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dc.authorscopusid56084894100
dc.authorscopusid57211906388
dc.authorscopusid57211591835
dc.authorscopusid16069377400
dc.contributor.authorÖzçağlayan, Ömer
dc.contributor.authorAltunan, Bengü
dc.contributor.authorKurtoğlu Özçağlayan, Tuğba İlkem
dc.contributor.authorÜnal, Aysun
dc.date.accessioned2023-04-20T08:02:30Z
dc.date.available2023-04-20T08:02:30Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjective: To investigate the vagus nerve (VN) dimensional changes with Parkinson's disease (PD), compared with healthy subjects. Additionally, it is important to investigate whether there is any relationships between these changes and patient's motor and non-motor symptoms (NMS) of PD. Materials and Methods: A cohort of 43 patients with PD formed a group that was compared with 44 patients without PD, denoted as the healthy subject (HS) group. The diameter and areas of VN of study groups were measured using ultrasonography (US). The study groups were further divided into <65 and >65 subgroups, to evaluate the possible effect of age on the VN and evaluated relationships of VN dimensions, between subgroups. In the PD group, a correlational analysis was conducted between the diameter and area of the VN and the motor and NMS scores. Results: There was statistically significant difference in right (P = .002) and left VN diameters (P = .007) and in right ( P = .001) and left VN areas (P = .007), between study groups. There was no significant difference in right and left VN diameters and the right and left VN areas, between subgroups. There was moderately negative correlation between gastrointestinal NMS scores and right VN area (r = -0.499, P = .002), left VN area (r = -0.499, P = .002), right VN diameter (r = -0.378, P = .023), left VN diameter (r = -0.385, P = .021), respectively. Conclusion: The US demonstrated that VN dimensions may possibly reduce in those patients affected by PD. In this cohort, it appears that an increase in gastrointestinal NMS scores may be explained by atrophy of the VN.
dc.identifier.doi10.1177/87564793221097008
dc.identifier.endpage505
dc.identifier.issn8756-4793
dc.identifier.issn1552-5430
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85132615846
dc.identifier.scopusqualityQ4
dc.identifier.startpage498
dc.identifier.urihttps://doi.org/10.1177/87564793221097008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10966
dc.identifier.volume38
dc.identifier.wosWOS:000796246500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAltunan, Bengü
dc.institutionauthorÜnal, Aysun
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Diagnostic Medical Sonography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVagus Nerve
dc.subjectParkinson's Disease
dc.subjectUltrasonography
dc.subjectNerve Diameter
dc.subjectNerve Atrophy
dc.subjectGut-Brain Axis
dc.subjectAxonal Degeneration
dc.subjectQuestionnaire
dc.subjectUltrasound
dc.subjectPathology
dc.titleThe Atrophy of the Vagus Nerve Correlated With Gastrointestinal Non-Motor Symptoms Scores, in Parkinson's Disease: A Sonography Research Study
dc.typeArticle

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