Protective effects of quercetin against arsenic-induced testicular damage in rats

Basit Öğe Kaydı
dc.authorscopusid57188730655
dc.authorscopusid26434076100
dc.authorscopusid25647609500
dc.authorscopusid24436194200
dc.authorscopusid7102765240
dc.authorscopusid6603048599
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorBaltaci, B. B.
dc.contributor.authorUygur, Ramazan
dc.contributor.authorÇağlar, Veli
dc.contributor.authorAktaş, C.
dc.contributor.authorAydın, M.
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:10:17Z
dc.date.available2022-05-11T14:10:17Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThis study investigated the effect of quercetin on changes in testes due to arsenic exposure. Twenty-seven male rats were divided into three groups: control (10 ml kg(-1) day(-1) saline), arsenic (10 mg kg(-1) day(-1) sodium arsenite) and arsenic + quercetin (arsenic + 50 mg kg(-1) day(-1) quercetin). The rats were sacrificed at the end of 15-day experiment. There was no difference between control group and arsenic group in body weight gain, testicular weight and serum total testosterone level. Quercetin treatment did not cause a significant difference in these parameters. In the arsenic group rats, we determined deterioration in the structure of seminiferous tubules, a decrease in the number of spermatogenic cells, an increase in the number of apoptotic cells, a decrease in the number of PCNA-positive cells, a decrease in SOD, CAT and GSH-Px activities, and an increase in the MDA level in testicular tissue. In all these changes, arsenic+quercetin group showed an improved compared to arsenic group. The amount of arsenic increased in the arsenic group was compared to the control group, and there was no difference between arsenic group and arsenic + quercetin group in the amount of arsenic. In conclusion, quercetin prevented arsenic-induced testicular damage with its anti-apoptotic and antioxidant effects.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects UnitNamik Kemal University [NKU-BAP.00.20.YL.14.01]
dc.description.sponsorshipThis study was supported by Namik Kemal University Scientific Research Projects Unit (Project Number: NKU-BAP.00.20.YL.14.01).
dc.identifier.doi10.1111/and.12561
dc.identifier.endpage1213
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10en_US
dc.identifier.pmid26992476
dc.identifier.scopus2-s2.0-84962525718
dc.identifier.scopusqualityQ2
dc.identifier.startpage1202
dc.identifier.urihttps://doi.org/10.1111/and.12561
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5349
dc.identifier.volume48
dc.identifier.wosWOS:000389219000019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBaltaci, B. B.
dc.institutionauthorUygur, Ramazan
dc.institutionauthorÇağlar, Veli
dc.institutionauthorAktaş, C.
dc.institutionauthorAydın, M.
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectarsenic
dc.subjectoxidative stress
dc.subjectquercetin
dc.subjecttestis
dc.subjectInduced Oxidative Stress
dc.subjectSodium Arsenite
dc.subjectGene-Expression
dc.subjectMethylated Metabolites
dc.subjectLipid-Peroxidation
dc.subjectChronic Ethanol
dc.subjectAscorbic-Acid
dc.subjectHeart-Disease
dc.subjectExposure
dc.subjectAntioxidant
dc.titleProtective effects of quercetin against arsenic-induced testicular damage in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5349.pdf
Boyut:
868.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu