Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings

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dc.authorscopusid34869282100
dc.authorscopusid8570900600
dc.authorscopusid8531050000
dc.authorscopusid57390458500
dc.authorscopusid55216749400
dc.authorscopusid57390431900
dc.authorscopusid57218879837
dc.contributor.authorBayrakçı, Nergiz
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorErdem, L.
dc.contributor.authorYıldırım, İlker
dc.contributor.authorGülen, Dumrul
dc.contributor.authorÇelikkol, Alive
dc.date.accessioned2022-05-11T14:05:11Z
dc.date.available2022-05-11T14:05:11Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractCoronavirus-related disease-2019 (COVID-19)-associated coagulopathy presents predominantly with thrombosis and leads to complications in close association with inflammatory process. Soluble endothelial protein C receptor (sEPCR), which is the soluble form of EPCR, reduces the anticoagulant and anti-inflammatory activity of activated protein C. The purpose of this study is to investigate the relationship between sEPCR and the laboratory parameters and thorax computed tomography (CT) findings in the course of COVID-19. Twenty-five laboratory-confirmed [reverse transcription-quantitative polimerase chain reaction (RT-qPCR) positive] and 24 clinically diagnosed (RT-qPCR negative) COVID-19 patients were enrolled in the study. Blood specimens were collected for sEPCR and haematological and biochemical parameter measurement. Thorax CT was performed to detect COVID-19 findings. These parameters from RT-qPCR positive and negative patients were then compared. Although there was no difference between the groups in terms of symptoms, the time between the onset of symptoms and the admission time was shorter in RT-qPCR positive group (P?=?0.000). sEPCR levels were significantly higher in the RT-qPCR positive group (P?=?0.011). Patients with ground-glass opacity and bilateral involvement on thorax CT have higher serum sEPCR levels (P?=?0.012 and 0.043, respectively). This study has shown for the first time that serum sEPCR levels, which is a member of coagulation cascade and has also been reported to be associated with inflammation, is higher in patients with positive RT-qPCR test and patients with GGO or bilateral involvement on thorax CT regardless of the PCR result. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
dc.identifier.doi10.1097/MBC.0000000000001070
dc.identifier.endpage555
dc.identifier.issn1473-5733
dc.identifier.issue8en_US
dc.identifier.pmid34321403
dc.identifier.scopus2-s2.0-85121958386
dc.identifier.scopusqualityQ3
dc.identifier.startpage550
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000001070
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4914
dc.identifier.volume32
dc.identifier.wosWOS:000756173900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikkol, Alive
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiological marker
dc.subjectendothelial protein C receptor
dc.subjectplasma protein
dc.subjectPROCR protein, human
dc.subjectadult
dc.subjectaged
dc.subjectblood
dc.subjectcomplication
dc.subjectdiagnostic imaging
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthuman
dc.subjectlung
dc.subjectmale
dc.subjectmiddle aged
dc.subjectsolubility
dc.subjectthrombophilia
dc.subjectvery elderly
dc.subjectx-ray computed tomography
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers
dc.subjectBlood Glucose
dc.subjectBlood Proteins
dc.subjectCOVID-19
dc.subjectEndothelial Protein C Receptor
dc.subjectFemale
dc.subjectHumans
dc.subjectLung
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSARS-CoV-2
dc.subjectSolubility
dc.subjectThrombophilia
dc.subjectTomography, X-Ray Computed
dc.titleRelationship between serum soluble endothelial protein C receptor level and COVID-19 findings
dc.typeArticle

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