Ozone treatment for high-dose systemic Steroid-Induced retinal injury

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dc.authorscopusid57204620975
dc.authorscopusid36115476100
dc.authorscopusid55838809000
dc.authorscopusid55752565900
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.contributor.authorYıldız, Aydın
dc.contributor.authorŞehitoğlu, Müşerref Hilal
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorArıkan, Sedat
dc.date.accessioned2022-05-11T14:48:37Z
dc.date.available2022-05-11T14:48:37Z
dc.date.issued2020
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractObjective To investigate the effect of high-dose systemic steroids on retinal tissues and the effectiveness of ozone (O-3) therapy. Methods Twenty-four New Zealand white rabbits were divided into three groups of eight. Group 1 was accepted as the control group, Group 2 received intramuscular 20 mg/kg methylprednisolone acetate and Group 3 received 14 sessions of ozone treatment in addition to methylprednisolone acetate. The subjects were sacrificed on the 30(th)day. Retinal tissues were removed. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) levels were evaluated for tissue biochemistry and serum ischaemic modified albumin (IMA), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) levels were evaluated with the ELISA method. Haematoxylin-eosin staining and TUNEL evaluation for apoptosis were evaluated as histopathological methods. Results In the treatment group, antioxidant parameters of TAS, SOD and CAT were higher, oxidative and ischaemic parameters of MDA, TOS and IMA were lower, inflammatory parameters of IL-6 and TNF-alpha were lower, retinal thickness was better and apoptosis amount was lower. Conclusion Apoptosis increases in retinal tissues due to high dose systemic steroid administration and the retina becomes thinner. With biochemical examination, oxidation parameters increased while antioxidant parameters decreased. Both histopathological and biochemical parameters improved significantly with ozone treatment.
dc.identifier.doi10.1080/15569527.2020.1790590
dc.identifier.endpage280
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue3en_US
dc.identifier.pmid32619116
dc.identifier.scopus2-s2.0-85087875646
dc.identifier.scopusqualityQ3
dc.identifier.startpage274
dc.identifier.urihttps://doi.org/10.1080/15569527.2020.1790590
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10664
dc.identifier.volume39
dc.identifier.wosWOS:000547737200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRetina
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectantioxidants
dc.subjectozone
dc.subjectH2o2-Induced Oxidative Stress
dc.subjectLens Epithelial-Cells
dc.subjectTrabecular Meshwork
dc.subjectIn-Vitro
dc.subjectApoptosis
dc.subjectTherapy
dc.subjectGlucocorticoids
dc.subjectMethylprednisolone
dc.subjectInflammation
dc.subjectCataract
dc.titleOzone treatment for high-dose systemic Steroid-Induced retinal injury
dc.typeArticle

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