Antiproliferative and Apoptotic Effects of Olive Leaf Extract Microcapsules on MCF-7 and A549 Cancer Cells

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dc.contributor.authorBal, Yildiz
dc.contributor.authorSurmeli, Yusuf
dc.contributor.authorSanli-Mohamed, Gulsah
dc.date.accessioned2024-10-29T17:58:31Z
dc.date.available2024-10-29T17:58:31Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractAlginate microcapsules are a talented means for the deliveryofbroad curative biomacromolecules. In this study, we immobilized oliveleaf extract (OLE) by calcium alginate (CA) and chitosan-coated CA(CCA) and characterized the OLE-loaded CA and CCA. The cytotoxic effect,the cell cycle arrest, and the apoptotic effect of OLE and its microcapsuleswere investigated against breast adenocarcinoma (MCF-7) and lung carcinoma(A549). As a result, the loading capacity of OLE-CA and OLE-CCAwas found to be 80 and 99%, respectively, in optimal conditions. Also,OLE-CA and OLE-CCA were characterized by unique FTIRpeaks and morphological display relative to the empty CCA microcapsules.The cytotoxicity analysis showed that the IC50 values ofOLE-CA and OLE-CCA were determined to be 312 and 0.94 & mu;g mL(-1) against A549, respectively, whereasthese were found to be 865.4 and 425.5 & mu;g mL(-1) for MCF-7 cells. On the other hand, the OLE microcapsules did notpossess in any concentration of cytotoxic influence on the BEAS 2Bhealthy cell line. Also, the exposure of OLE-CCA to MCF-7 andA549 resulted in the arrest of more MCF-7 and A549 cells at the G0/G1phase compared to the OLE. A549 and MCF-7 cells were predominantlyfound in the late apoptosis phase and necrosis phase, respectively.Optical microscopy images confirmed that OLE microcapsules were moreeffective against MCF-7 and A549 than free OLE. The present work suggestedthat the OLE microcapsules might be administered as nutrition supplementsfor cancer therapy.en_US
dc.identifier.doi10.1021/acsomega.3c01493
dc.identifier.endpage28993en_US
dc.identifier.issn2470-1343
dc.identifier.issue32en_US
dc.identifier.pmid37599941en_US
dc.identifier.scopus2-s2.0-85167883055en_US
dc.identifier.startpage28984en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c01493
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14368
dc.identifier.volume8en_US
dc.identifier.wosWOS:001041106400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlginateen_US
dc.subjectDeliveryen_US
dc.subjectChitosanen_US
dc.subjectAntioxidantsen_US
dc.subjectOleuropeinen_US
dc.titleAntiproliferative and Apoptotic Effects of Olive Leaf Extract Microcapsules on MCF-7 and A549 Cancer Cellsen_US
dc.typeArticleen_US

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