Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

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dc.authorscopusid23494580100
dc.authorscopusid36617408300
dc.authorscopusid15020620800
dc.authorscopusid8440302700
dc.authorscopusid7102765266
dc.authorscopusid6701753460
dc.contributor.authorAlici, Özlem
dc.contributor.authorKavaklı, Havva Sahin
dc.contributor.authorKoca, Cemile
dc.contributor.authorAltıntaş, Neriman Defne
dc.contributor.authorAydın, Murat
dc.contributor.authorAlici, Süleyman
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 mu mol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNFalpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.
dc.identifier.doi10.1155/2015/810948
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.pmid25948886
dc.identifier.scopus2-s2.0-84928485504
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2015/810948
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9215
dc.identifier.volume2015
dc.identifier.wosWOS:000353135000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Murat
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofMediators of Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInduced Lung Injury
dc.subjectOxidative Stress
dc.subjectSuperoxide-Dismutase
dc.subjectAntioxidant Therapy
dc.subjectSeptic Shock
dc.subjectPropolis
dc.subjectDamage
dc.subjectCells
dc.subjectCape
dc.subjectMice
dc.titleValue of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats
dc.typeArticle

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