Role of sympathetic cotransmitter galanin on autonomic balance in heart failure: an active player or a bystander?

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dc.authorscopusid55317577700
dc.authorscopusid57196352297
dc.authorscopusid16315021800
dc.authorscopusid23968920100
dc.authorscopusid6505680586
dc.authorscopusid7005837198
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorSagbas, Miray
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüler, Niyazi
dc.date.accessioned2022-05-11T14:14:05Z
dc.date.available2022-05-11T14:14:05Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Galanin, a cotransmitter similar to neuropeptide Y (NPY), aggravates autonomic imbalance in systolic heart failure (HF) by attenuating vagal tonus after burst sympathetic activity. In animal HF models, galanin antagonists have improved cardiac function. To determine whether galanin is a promising therapeutic target in HF, we studied its concentrations in HF patients and evaluated its correlation with NPY, markers of humoral activity such as pro-BNP and copeptin, and echocardiographic parameters of HF severity. Methods: After recording demographic and echocardiographic characteristics of 87 individuals (57 HF patients and 30 control subjects), fasting serum concentrations of galanin, NPY, copeptin, and pro-BNP were determined. Results: Unlike pro-BNP, copeptin, and NPY, which were significantly elevated in HF patients (p<0.001, p<0.001, and p=0.001, respectively), galanin was similar in HF patients and control subjects (p=0.9). NPY correlated with the echocardiographic parameters of HF severity (r=-0.22, p=0.03 for EF; r=0.3, p=0.005 for Tei index of RV; r=-0.23, p=0.03 for TAPSE; and r=0.24, p=0.024 for E/e') and pro-BNP (r=0.22, p=0.046). NPY levels were also associated with beta blocker (BB) use, wherein BB significantly decreased NPY in both HF patients and control subjects. Galanin correlated with humoral biomarkers, pro-BNP and copeptin (r=0.39, p<0.001 and r=0.41, p<0.001, respectively). Although current smoking, BB therapy, pro-BNP, copeptin, and body mass index were associated with galanin in univariate analyses, the multiple linear regression model revealed that pro-BNP was the only significant determinant of galanin levels in HF patients. Conclusion: Our findings confirmed the role of NPY in autonomic balance and suggest that galanin is associated with the proadrenergic state, but its role in HF in humans remains unclear.
dc.description.sponsorshipScientific Research Projects Fund of Namik Kemal University [NKUBAP.02.YL.16.046]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Fund of Namik Kemal University (NKUBAP.02.YL.16.046).
dc.identifier.doi10.14744/AnatolJCardiol.2017.7831
dc.identifier.endpage288
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue4en_US
dc.identifier.pmid28811392
dc.identifier.scopus2-s2.0-85032731076
dc.identifier.scopusqualityQ3
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2017.7831
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5772
dc.identifier.volume18
dc.identifier.wosWOS:000417874800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorSagbas, Miray
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüler, Niyazi
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectheart failure
dc.subjectgalanin
dc.subjectneuropeptide Y
dc.subjectsympathovagal crosstalk
dc.subjectPlasma Neuropeptide-Y
dc.subjectHypothalamic Magnocellular Neurons
dc.subjectVagus Nerve-Stimulation
dc.subjectNatriuretic Peptide
dc.subjectRelease
dc.subjectRats
dc.subjectNpy
dc.titleRole of sympathetic cotransmitter galanin on autonomic balance in heart failure: an active player or a bystander?
dc.typeArticle

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