Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats

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dc.authorid0000-0001-6708-1229
dc.authorscopusid8855691800
dc.authorscopusid57209480678
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorKaraboğa, İhsan
dc.date.accessioned2022-05-11T14:15:41Z
dc.date.available2022-05-11T14:15:41Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractThe trinitrobenzene sulfonic acid (TNBS) induced colitis model is used to investigate the pathogenesis of ulcerative colitis. Colon inflammation and apoptosis are associated with tissue damage in ulcerative colitis. Hesperetin is a natural flavonoid that exhibits antioxidative, anti-inflammatory and anti-apoptotic properties. We investigated the effects of hesperetin on tumor necrosis factor-alpha (TNF-), protein tyrosine phosphatase, receptor type C (CD45), caspase-3 and Bax expressions in TNBS in induced colitis model in rats. Male rats were divided into three groups: control group treated with 1ml physiological saline, colitis group, and colitis +hesperetin group treated with TNBS and hesperetin. Hesperetin treatment was applied for 10days starting 3days prior to colitis induction. At the end of the experiment, TNF-, CD45, caspase-3 and Bax expressions in colon tissue were determined using indirect immunohistochemistry. Increased immunoreactivity of both inflammation markers, TNF-, CD45, and apoptotic markers, caspase-3 and Bax, was detected in the colitis group. Hesperetin treatment effected significant reduction of all parameters. Hesperetin treatment prevents colon damage owing to its anti-inflammatory and anti-apoptotic effects.
dc.description.sponsorshipNamik Kemal University, Scientific Research Projects Commission [NKUBAP.02, 17.085]
dc.description.sponsorshipThis study was supported by Namik Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.02.GA.17.085
dc.identifier.doi10.1080/10520295.2018.1530454
dc.identifier.endpage158
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid30383440
dc.identifier.scopus2-s2.0-85056079121
dc.identifier.scopusqualityQ2
dc.identifier.startpage151
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1530454
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6024
dc.identifier.volume94
dc.identifier.wosWOS:000469009000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectBax
dc.subjectcaspase-3
dc.subjectCD45
dc.subjectcolitis
dc.subjectrats
dc.subjectTNBS
dc.subjectTNF-alpha
dc.subjectTnbs-Induced Colitis
dc.subjectUlcerative-Colitis
dc.subjectTnf-Alpha
dc.subjectModel
dc.subjectInflammation
dc.subjectAntioxidant
dc.subjectHesperidin
dc.subjectBcl-2
dc.subjectPathogenesis
dc.subjectExpression
dc.titleImmunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats
dc.typeArticle

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