The gut microbiome in epilepsy

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dc.authorscopusid16550520100
dc.authorscopusid57211906388
dc.authorscopusid37058172000
dc.authorscopusid55664492500
dc.contributor.authorŞafak, Birol
dc.contributor.authorAltunan, Bengü
dc.contributor.authorTopçu, Birol
dc.contributor.authorTopkaya, Aynur Eren
dc.date.accessioned2022-05-11T14:02:43Z
dc.date.available2022-05-11T14:02:43Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe close relationship between epilepsy and autoimmune diseases and the fact that the cause of epilepsy is idiopathic in 60% of cases suggest that intestinal microbiota may play a role in the etiology of epilepsy. In this study, we analyzed and compared the intestinal microbiota composition of patients with idiopathic focal epilepsy (n = 30) and healthy volunteer group (n = 10) by 16s ribosomal DNA sequencing. Proteobacteria phylum was found to be higher in patients with epilepsy (25.4%) than in healthy volunteers group (1.5%). The genera of Campylobacter, Delftia, Haemophilus, Lautropia, Neisseria among Proteobacteria phylum were found to be statistically significantly higher in patients with epilepsy than in healthy volunteers (p < 0.05). Fusobacteria phylum was detected in 10.6% of the patients with epilepsy but not in the healthy volunteer group. The genus of the Fusobacteria phylum was found as Leptotrichia and Fusobacterium. In our study, taxonomic drift and significant differences in the intestinal microbiota of patients with epilepsy according to healthy volunteer group showed that autoimmune mechanisms and inflammation may have a role in the etiology of epilepsy. Our data should be supported by other studies as to the role of the intestinal microbiome in the prevention and treatment of epilepsy. © 2019 Elsevier Ltd
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit, FÃœBAP
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of the Tekirdağ Namık Kemal University in Turkey. Project Number: NKUBAP.02.GA. 8.186.
dc.identifier.doi10.1016/j.micpath.2019.103853
dc.identifier.issn0882-4010
dc.identifier.pmid31730997
dc.identifier.scopus2-s2.0-85075324324
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.micpath.2019.103853
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4451
dc.identifier.volume139
dc.identifier.wosWOS:000514245100020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞafak, Birol
dc.institutionauthorAltunan, Bengü
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherAcademic Press
dc.relation.ispartofMicrobial Pathogenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject16S rRNA gene
dc.subjectAutoimmunity
dc.subjectCentral nervous system
dc.subjectEpilepsy
dc.subjectGut microbiota
dc.subjectDNA 16S
dc.subjectribosome DNA
dc.subjectRNA 16S
dc.subjectadult
dc.subjectArticle
dc.subjectBacteroides
dc.subjectBlautia
dc.subjectCampylobacter
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectCoprococcus
dc.subjectDelftia
dc.subjectDNA sequence
dc.subjectepilepsy
dc.subjectFaecalibacterium
dc.subjectfemale
dc.subjectfollow up
dc.subjectFusobacterium
dc.subjectHaemophilus
dc.subjecthuman
dc.subjectintestine flora
dc.subjectLautropia
dc.subjectLeptotrichia
dc.subjectmale
dc.subjectNeisseria
dc.subjectParabacteroides
dc.subjectphylum
dc.subjectpriority journal
dc.subjectProteobacteria
dc.subjectRuminococcus
dc.subjectspecies composition
dc.subjectautoimmunity
dc.subjectbacterium
dc.subjectcentral nervous system
dc.subjectclassification
dc.subjectepilepsy
dc.subjectgastrointestinal tract
dc.subjectgenetics
dc.subjectimmunology
dc.subjectintestine flora
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectAdult
dc.subjectAutoimmunity
dc.subjectBacteria
dc.subjectCentral Nervous System
dc.subjectDNA, Ribosomal
dc.subjectEpilepsy
dc.subjectGastrointestinal Microbiome
dc.subjectGastrointestinal Tract
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProteobacteria
dc.subjectRNA, Ribosomal, 16S
dc.subjectSequence Analysis, DNA
dc.titleThe gut microbiome in epilepsy
dc.typeArticle

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