The maxillary sinus after total laryngectomy: an electron microscopic study

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dc.authorid0000-0003-4064-7637
dc.authorscopusid56216670100
dc.authorscopusid16302175700
dc.authorscopusid22633901300
dc.authorscopusid54888854000
dc.authorscopusid22935333800
dc.authorscopusid55665469400
dc.authorscopusid26326260800
dc.authorwosidGüvenç, Işıl Adadan/S-2103-2016
dc.authorwosidBagriyanik, Husnu Alper/H-7577-2013
dc.contributor.authorÖzdemir, İsmail
dc.contributor.authorÖztürkcan, Sedat
dc.contributor.authorBağrıyanık, Alper
dc.contributor.authorBaşoğlu, Sinan
dc.contributor.authorÖzkul, Yılmaz
dc.contributor.authorGüvenç, Işıl Adadan
dc.contributor.authorÖzoğul, Candan
dc.date.accessioned2022-05-11T14:36:03Z
dc.date.available2022-05-11T14:36:03Z
dc.date.issued2010
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractNasal breathing is completely ceased after total laryngectomy. This results in some structural changes in the nasal mucosa, which has been described in numerous studies. This study investigates the changes that appear in the paranasal sinus mucosa. Eight patients who had undergone total laryngectomy at least 1-year ago were enrolled. Under general anesthesia, maxillary sinuses were examined with an endoscope inserted through canine fossa. 1-2 mm mucosal tissues for biopsy were taken from posterior wall of the maxillary sinus. Specimens were evaluated under an electron microscope. Control tissues for biopsy were obtained from two patients who had been operated for other reasons and analyzed under transmission electron microscopy. Results showed that in the control specimens, the epithelial cells appeared normal under transmission electron microscopy. Samples taken from two larygectomees in their first postoperative year were also completely normal. Samples from other larygectomees demonstrated ciliary loss, abundant degenerative vacuoles in ciliated epithelial cells and detachments in the interepithelial junctional complexes. The intracellular respiratory mechanisms such as the mitochondria, golgi complex and endoplasmic reticulum cisternae, and the integrity of the cellular or the nuclear membrane were spared. We conclude that the cessation of nasal breathing resulted in degenerative changes that could be reversible in the transmission electron microscopic examination of maxillary sinus mucosa. These changes emerged after 2 years following total laryngectomy. Nevertheless, these changes did not have any negative influence on the clinical outcome in this group of patients.
dc.identifier.doi10.1007/s00405-009-1128-z
dc.identifier.endpage720
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue5en_US
dc.identifier.pmid19851778
dc.identifier.scopus2-s2.0-77954542825
dc.identifier.scopusqualityQ1
dc.identifier.startpage715
dc.identifier.urihttps://doi.org/10.1007/s00405-009-1128-z
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8353
dc.identifier.volume267
dc.identifier.wosWOS:000275954000009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, İsmail
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTotal laryngectomy
dc.subjectElectron microscope
dc.subjectMaxillary sinus mucosa
dc.subjectSurgery
dc.subjectCilia
dc.subjectNose
dc.titleThe maxillary sinus after total laryngectomy: an electron microscopic study
dc.typeArticle

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