The comparison of vep parameters in neuromyelitis optica spectrum disorders and multiple sclerosis patients with acute optic neuritis

Basit Öğe Kaydı
dc.authorscopusid6603040523
dc.authorscopusid57211906388
dc.authorscopusid57220069864
dc.contributor.authorTurgut, Nilda
dc.contributor.authorAltunan, Bengü
dc.contributor.authorGündoğdu, Aksoy
dc.date.accessioned2022-05-11T14:40:18Z
dc.date.available2022-05-11T14:40:18Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIntroduction: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are idiopathic, autoimmune, and central nervous system inflammatory diseases. The similarity in the clinical course of both diseases creates difficulties in the differential diagnosis. Pattern reversal visual evoked potentials (VEP) are used at this stage. This study aimed to investigate VEP’s role in the differential diagnosis of MS and NMOSD when the patients apply with acute optic neuritis. Method: The data of 15 relapsing-remitting MS patients (RRMS) and 10 NMOSD patients (1 seropositive patient) presenting with blurred vision and who were diagnosed with acute optic neuritis were retrospectively analyzed. Demographic, disease, and VEP characteristics of the patients were recorded. Results: According to retrospective data obtained from NMOSD patients, the mean P100 latency was 117.3 ± 12.3, and the mean amplitude was 6.1 ± 3.5. When the VEP characteristics obtained from 15 RRMS patients were evaluated, the P100 latency was 131.7 ± 17.3, and the mean P100 amplitude was 8.0 ± 3.0. P100 latency was significantly prolonged in the RRMS group than the NMOSD group, and amplitude was significantly lower in the NMOSD group than the RRMS group. Discussion: Differentiating NMOSD patients with optic neuritis from MS in the early period is very important for preventing permanent visual damage, initiating appropriate treatment, planning treatment, and predicting prognosis. VEP findings in early-stage acute optic neuritis can be used to differentiate clinically challenging both seropositive and seronegative NMOSD patients from patients with MS. © 2020, Istanbul Universitesi. All rights reserved.
dc.identifier.doi10.5455/NYS.20200307085847
dc.identifier.endpage4
dc.identifier.issn1300-8773
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85096779124
dc.identifier.scopusqualityN/A
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.5455/NYS.20200307085847
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8932
dc.identifier.volume58
dc.indekslendigikaynakScopus
dc.institutionauthorTurgut, Nilda
dc.institutionauthorAltunan, Bengü
dc.institutionauthorGündoğdu, Aksoy
dc.language.isoen
dc.publisherIstanbul Universitesi
dc.relation.ispartofYeni Symposium
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeuromyelitis optica spectrum disorders
dc.subjectP100 amplitude
dc.subjectP100 latency
dc.subjectPattern reversal visual evoked potentials
dc.subjectRelapsing-remitting multiple sclerosis
dc.subjectaquaporin 4 antibody
dc.subjectimmunoglobulin G
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectblurred vision
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectdisease duration
dc.subjectelectrical potential parameters
dc.subjectExpanded Disability Status Scale
dc.subjectfemale
dc.subjecthuman
dc.subjectlatent period
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectmyelooptic neuropathy
dc.subjectneurophysiology
dc.subjectoccipital cortex
dc.subjectoptic neuritis
dc.subjectprognosis
dc.subjectretrospective study
dc.subjecttreatment planning
dc.subjectvisual evoked potential
dc.titleThe comparison of vep parameters in neuromyelitis optica spectrum disorders and multiple sclerosis patients with acute optic neuritis
dc.title.alternativeAkut optik nöritli multipl skleroz ve nöromiyelitis optika spektrum bozuklukları hasta-larında vep parametrelerinin karşılaştırılması]
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu