Psychophysical correspondence between vibrotactile intensity and intracortical microstimulation for tactile neuroprostheses in rats

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dc.authorid0000-0003-4119-617X
dc.authorid0000-0002-7757-5764
dc.authorscopusid55597343100
dc.authorscopusid6603560243
dc.authorwosidDEVECIOGLU, ISMAIL/H-4523-2018
dc.contributor.authorDevecioğlu, İsmail
dc.contributor.authorGüçlü, Burak
dc.date.accessioned2022-05-11T14:16:03Z
dc.date.available2022-05-11T14:16:03Z
dc.date.issued2017
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractObjective. Recent studies showed that intracortical microstimulation (ICMS) generates artificial sensations which can be utilized as somatosensory feedback in cortical neuroprostheses. To mimic the natural psychophysical response, ICMS parameters are modulated according to psychometric equivalence functions (PEFs). PEFs match the intensity levels of ICMS and mechanical stimuli, which elicit equal detection probabilities, but they typically do not include the frequency as a control variable. We aimed to establish frequencydependent PEFs for vibrotactile stimulation of the glabrous skin and ICMS in the primary somatosensory cortex of awake freely behaving rats. Approach. We collected psychometric data for vibrotactile and ICMS detection at three stimulation frequencies (40, 60 and 80 Hz). The psychometric data were fitted with a model equation of two independent variables (stimulus intensity and frequency) and four subject-dependent parameters. For each rat, we constructed a separate PEF which was used to estimate the ICMS current amplitude for a given displacement amplitude and frequency. The ICMS frequency was set equal to the vibrotactile frequency. We validated the PEFs in a modified task which included randomly selected probe trials presented either with a vibrotactile or an ICMS stimulus, and also at frequencies and intensity levels not tested before. Main results. The PEFs were generally successful in estimating the ICMS current intensities (no significant differences between vibrotactile and ICMS trials in Kolmogorov-Smirnov tests). Specifically, hit rates from both trial conditions were significantly correlated in 86% of the cases, and 52% of all data had perfect match in linear regression. Significance. The psychometric correspondence model presented in this study was constructed based on surface functions which define psychophysical detection probability as a function of stimulus intensity and frequency. Therefore, it may be used for the real-time modulation of the frequency and intensity of ICMS pulses in somatosensory neuroprostheses.
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113S901]; Bogazici University BAPBogazici University [15XD2]
dc.description.sponsorshipThis study is supported by TUBITAK grant no: 113S901 and Bogazici University BAP no: 15XD2 given to Dr Guclu. We thank Bige Vardar, Sevgi Ozturk, and Samet Kocaturk for their help with the experiments.
dc.identifier.doi10.1088/1741-2552/14/1/016010
dc.identifier.issn1741-2560
dc.identifier.issn1741-2552
dc.identifier.issue1en_US
dc.identifier.pmid27991426
dc.identifier.scopus2-s2.0-85010471364
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1088/1741-2552/14/1/016010
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6165
dc.identifier.volume14
dc.identifier.wosWOS:000391582500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDevecioğlu, İsmail
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofJournal of Neural Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsomatosensory
dc.subjectneuroprosthesis
dc.subjectpsychometric equivalence function
dc.subjectvibrotactile stimulation
dc.subjectintracortical microstimulation
dc.subjectfreely behaving rat
dc.subjectglabrous skin
dc.subjectAdapting Mechanoreceptive Fibers
dc.subjectPrimary Somatosensory Cortex
dc.subjectPacinian-I-Channel
dc.subjectGlabrous Skin
dc.subjectCortical Microstimulation
dc.subjectDetection Thresholds
dc.subjectBrain Interface
dc.subjectPrecision Grip
dc.subjectDiscrimination
dc.subjectHand
dc.titlePsychophysical correspondence between vibrotactile intensity and intracortical microstimulation for tactile neuroprostheses in rats
dc.typeArticle

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