Prognostic factors influencing regorafenib treatment outcomes in metastatic colorectal cancer

Basit Öğe Kaydı
dc.contributor.authorKaraboyun, Kubilay
dc.contributor.authorYolcu, Ahmet
dc.date.accessioned2024-10-29T17:50:31Z
dc.date.available2024-10-29T17:50:31Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractAim: We aimed to determine the efficacy and prognostic factors of Regorafenib in advanced colorectal cancer patients. Materials and Methods: This study was designed as single-center and retrospective. The study included 72 patients with metastatic colorectal cancer treated with Regorafenib. Univariate and multivariate analyses of factors affecting survival were generated by Cox Regression Models. Results: Twenty-three (31.9%) of the patients were female, the median age was 65 years. The median progression-free survival (PFS) and overall survival (OS) were 4.13 and 8.7 months, respectively. The carcinoembryonic antigen (CEA) level (p=0.001), and Eastern Cooperative Oncology Group (ECOG) score (p<0.001) were found to be prognostic in the multivariate model for PFS. ECOG (p<0.001), CEA level (p<0.001), dose reduction (p=0.003), and side of the primary tumor (p=0.037) were prognostic for OS. Conclusion: Our study revealed that ECOG, requiring dose reduction during the treatment, and lower baseline CEA levels were found to be prognostic.en_US
dc.identifier.doi10.30569/adiyamansaglik.1355856
dc.identifier.endpage205en_US
dc.identifier.issn2458-9179
dc.identifier.issue3en_US
dc.identifier.startpage199en_US
dc.identifier.trdizinid1231561en_US
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1355856
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1231561
dc.identifier.urihttps://hdl.handle.net/20.500.11776/13041
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurvivalen_US
dc.subjectRegorafeniben_US
dc.subjectAdvanced colorectal canceren_US
dc.titlePrognostic factors influencing regorafenib treatment outcomes in metastatic colorectal canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu