Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0003-2112-4056
dc.authorscopusid57200105522
dc.authorscopusid56715752200
dc.authorscopusid35197435300
dc.authorscopusid55767454000
dc.authorscopusid57004462100
dc.authorscopusid57190404723
dc.authorscopusid56117583100
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidYildirim, Tulay/AAB-5030-2021
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorBilir, Bülent
dc.contributor.authorBilir, Betül Ekiz
dc.contributor.authorYılmaz, I.
dc.contributor.authorAtile, N. Soysal
dc.contributor.authorYıldırım, Tülay
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorAydın, M.
dc.date.accessioned2022-05-11T14:10:00Z
dc.date.available2022-05-11T14:10:00Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Diabetic peripheral neuropathy is a common complication of type-2 diabetes mellitus. Endocan, apelin and endoglin are thought to be associated with endothelial dysfunction, angiogenesis and inflammation. In this study, we planned to evaluate these markers in diabetic peripheral neuropathy patients. PATIENTS AND METHODS: This single-blind, controlled clinical study was conducted on 99 type 2 diabetic patients with or without diabetic peripheral neuropathy and 53 healthy volunteer controls. Physical and laboratory examinations were done in all groups. In these groups, Endoglin, apelin and endocan levels were measured with ELISA method. RESULTS: Endoglin, apelin and endocan concentrations in diabetic peripheral neuropathy patients were higher than other diabetes mellitus patients and healthy controls. Similarly, diabetes mellitus patient's endoglin, apelin and endocan levels were higher than healthy controls. The differences were statistically significant. We detected a significant positive correlation between endoglin, apelin and endocan levels in all groups. CONCLUSIONS: Endoglin, apelin and endocan may reflect angiogenesis and endothelial dysfunction in diabetic peripheral neuropathy and they may be used as a marker in the future.
dc.description.sponsorshipScientific Research Fund of Namik Kemal UniversityNamik Kemal University [NKUBAP.00.20.AR.15.08]
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Namik Kemal University (project number NKUBAP.00.20.AR.15.08).
dc.identifier.endpage898
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid27010147
dc.identifier.scopus2-s2.0-85017011325
dc.identifier.scopusqualityQ2
dc.identifier.startpage892
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5246
dc.identifier.volume20
dc.identifier.wosWOS:000373350100020
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilir, Bülent
dc.institutionauthorYıldırım, Tülay
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorAydın, M.
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApelin
dc.subjectEndocan
dc.subjectEndoglin
dc.subjectDiabetic peripheral neuropathy
dc.subjectType-2 diabetes mellitus
dc.subjectSoluble Endoglin
dc.subjectBiomarker
dc.subjectPlasma
dc.subjectInflammation
dc.subjectExpression
dc.subjectCells
dc.titleAssociation of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients
dc.typeArticle

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