Tumor Necrosis Factor-Alpha and Interleukin 6 localization in the Umbilical Cord Tissue of Pregnant Women with Preeclampsia: Smokers and Non-smokers

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dc.contributor.authorYediel-Aras, Suekran
dc.contributor.authorGoktug, Berrin
dc.contributor.authorGezer, Arzu
dc.contributor.authorBakir, Buket
dc.contributor.authorKaradag-Sari, Ebru
dc.date.accessioned2025-04-06T12:24:02Z
dc.date.available2025-04-06T12:24:02Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: In this study, the localization of tumor necrosis factor alpha (TNF- alpha) and interleukin (IL)-6 in the umbilical cord tissue of pregnant women with preeclampsia who smoke and in those who do n'ot smoke was investigated using immunohistochemical methods. Methods: The sample groups consisted of a control group, cigarette smokers, preeclampsia, and cigarette smokers with preeclampsia. Histological and immunohistochemical methods were applied to the tissue samples. Results: It was determined that there were varying degrees of edematous change in the layers of arteries and veins in the preeclampsia and the cigarette smokers with preeclampsia groups, with a statistically significant level of difference in thickness compared to the other groups. In addition, different levels of TNF-alpha and IL-6 immunoreactivity were detected in the umbilical cord tissue across all the groups. In the preeclampsia group, TNF-alpha immunoreactivitywas found to increase in the arterial muscle layer. Moreover, IL-6 immunoreactivity was found to decrease in the arterial endothelium and muscle layers in the cigarette smokers, preeclampsia, and cigarette smokers with preeclampsia groups and increase in the venous endothelium and muscle layers. In addition, immunoreactivity increased in the amniotic epithelium in the cigarette smokers with preeclampsia group. Discussion: In conclusion, the differences in cytokine levels between the cigarette smokers, preeclampsia, and cigarette smokers with preeclampsia groups were thought to be caused by responses of the maternal immune system and histopathological changes in the umbilical cord tissue.
dc.identifier.endpage220
dc.identifier.issn0738-0658
dc.identifier.issn2373-6011
dc.identifier.issue4
dc.identifier.pmid39671415
dc.identifier.scopus2-s2.0-85212144973
dc.identifier.scopusqualityQ3
dc.identifier.startpage214
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17293
dc.identifier.volume43
dc.identifier.wosWOS:001380192600007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Puerto Rico Medical Sciences Campus
dc.relation.ispartofPuerto Rico Health Sciences Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250406
dc.subjectIL-6
dc.subjectPreeclampsia
dc.subjectSmoker
dc.subjectTNF-alpha
dc.subjectUmbilical cord
dc.titleTumor Necrosis Factor-Alpha and Interleukin 6 localization in the Umbilical Cord Tissue of Pregnant Women with Preeclampsia: Smokers and Non-smokers
dc.typeArticle

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