The concept of metabolomics
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Date
2023
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Publisher
Nova Science Publishers, Inc.
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info:eu-repo/semantics/closedAccess
Abstract
Responses provided by living beings to environmental stimuli and other effects can exhibit variation. Sufficiently convincing explanations for the physiological reasons for such variation could not be obtained from studies utilizing transcriptomics or proteomics. The final part of the physiological cascade of a given mechanism is open to environmental effects. Metabolites can be used to evaluate such changes. Detailed investigations and categorizing metabolites are now possible due to the development of analytical techniques, which pave the way for metabolomic studies. Metabolomics is a sub-branch in the field of systems biology. Metabolomics defines the comprehensive categorization of metabolites that are formed by genomic mechanisms and interactions with environmental stimuli. In recent years, novel tools and databases have been developed to enable the confident analysis, identification, and quantification of metabolites from various sources (e.g., plants, animals, humans, foods, and environment) and to process large-scale data sets for easier access. The core of systems biology includes blending data provided by omics (e.g., transcriptomics, proteomics, nutrigenomics, lipidomics, glycomics, interactomics, and fluxomics) with bioinformatic processing. Today, metabolomics is extensively used in various research areas, including diagnostics, biomarker identification, cancer research, genetic disorders, metabolic pathway research, pharmaceutical research, toxicity determination, animal science, and agricultural and nutritional research. © 2023 Nova Science Publishers, Inc. All rights reserved.
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Keywords
Metabolites, Metabolomics, Omics, Systems biology
Journal or Series
Metabolomics and Clinical Approach
